Search for dissertations about: "trypanosomatids"

Found 5 swedish dissertations containing the word trypanosomatids.

  2. 1. A Study on Trypanosomal Polyamine Biosynthetic Enzymes

    Author : Sima Nasizadeh; Biogena aminer; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell cycle; protein turnover; trypanosomatids; polyamines; Ornithine decarboxylase; S-adenosylmethione decarboxylase; Parasitology human and animal ; Parasitologi människa och djur ;

    Abstract : The polyamines, putrescine, spermidine, and spermine, are essential for all forms of life. The polyamine biosynthetic pathway has been shown to be a potential target for drugs against various trypanosomal parasitic diseases. READ MORE

  4. 2. Immunobiochemical significance of Trypanosoma rangeli in the study of Trypanosoma cruzi

    Author : Azael Patiño Saldaña; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Trypanosoma rangeli is a haemoflagellate that infects humans nonpathogenically in some areas in which T. cruzi, the causative agent of Chagas' disease, is endemic. Since common biological and immunochemical characteristics have been described for these parasites, a detailed study of their relationship is needed. READ MORE

  5. 3. Genomic feature identification in trypanosomatid parasites

    Author : Daniel Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Trypanosoma cruzi; genome sequence; bioinformatics; gene finding; Trypanosoma brucei; Leishmania major; strand asymmetry; trans splicing; polyadenylation; post-transcriptional control; uAUGs.;

    Abstract : The trypanosomatid parasites cause death and suffering, among humans as well as livestock. Current drugs lack efficacy and cause severe side effects, and no vaccines are available. Increased knowledge of the biology of the parasites is vital for the development of new drugs. READ MORE

  6. 4. Trypanosoma cruzi genome plasticity and evolution

    Author : Carlos Talavera-López; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Trypanosoma cruzi, a protozoan from the Kinetoplastidae family, is the etiologic agent of Chagas disease, a major public health problem affecting mostly the poorest areas of Latin America. Due to the complex nature of the parasite’s genome it has been impossible to produce a complete reference genome sequence, thus hampering the implementation of post- genomic approaches to unveil the mechanisms of generation of antigenic variation and the identification of new drug targets. READ MORE

  7. 5. SARs for the Antiparasitic Plant metabolite Pulchrol

    Author : Paola Terrazas Villarroel; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; pulchrol; pulchral; SARs; antiparasitic; Leishmania braziliensis; Leishmania amazonensis; Trypanozoma cruzi; Bourreria pulchra; Leishmaniasis; Chagas disease; Synthesis; Pharmacophore; ADMET;

    Abstract : Pulchrol, a natural compound isolated from the roots of the vegetal specie Bourreria pulchra has been shown to possess potential antiparasitic activity toward Trypanosomatids, particularly against Trypanosoma cruzi, which causes the Chagas disease; and moderately against Leishmania species, responsible for Leishmaniasis. In this investigation, several pulchrol analogues were prepared and assayed toward T. READ MORE