Search for dissertations about: "trypanosomiasis"

Showing result 1 - 5 of 16 swedish dissertations containing the word trypanosomiasis.

  1. 1. Novel treatment of African trypanosomiasis

    Author : Suman Kumar Vodnala; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Human African Trypanosomiasis (HAT) or Sleeping Sickness is fatal if untreated. Current drugs used for the treatment of HAT have difficult treatment regimens and unacceptable toxicity related issues. READ MORE

  2. 2. Microfluidic Cell and Particle Sorting using Deterministic Lateral Displacement

    Author : Stefan Holm; Fasta tillståndets fysik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Microfluidics; Separation science; Deterministic Lateral Displacement; Cell analysis; Deterministic lateral displacement; Microfluidics; Particle sorting; Droplet microfluidics; trypanosomiasis; red blood cell; Cell sorting; Fysicumarkivet A:2018:Holm;

    Abstract : Microfluidics is a field which has the potential to revolutionize medical diagnostics. The ability to sort and analyse cells by the use of portable handheld devices has the potential to enable sensitive devices for point-of-care diagnostics. READ MORE

  3. 3. Salvage and de novo synthesis of nucleotides in Trypanosoma brucei and mammalian cells

    Author : Artur Fijolek; Lars Thelander; Arne Holmgren; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; nucleotides; ribonucleotide reductase; Ara-A; p53R2; Trypanosoma brucei; African sleeping sickness; trypanosomiasis; CTP synthetase; adenosine kinase; acivicin; adenine arabinoside; Biochemistry; Biokemi;

    Abstract : All living cells are dependent on nucleic acids for their survival. The genetic information stored in DNA is translated into functional proteins via a messenger molecule, the ribonucleic acid (RNA). Since DNA and RNA can be considered as polymers of nucleotides (NTPs), balanced pools of NTPs are crucial to nucleic acid synthesis and repair. READ MORE

  4. 4. Immunopathology and signalling molecules involved during experimental African trypanosomiasis

    Author : Ragaa Abdelkhalig Eltayeb; Karolinska Institutet; Karolinska Institutet; []
    Keywords : African Trypanosomiasis; Cytokines; Chemokines; Co-stimulatory molecules; Immunopathogenesis; T.b. brucei;

    Abstract : In humans, African trypanosomiasis occurs in two forms; the chronic West African form is caused by T.b. gambiense and the acute or subacute East African form is caused by T.b. READ MORE

  5. 5. Oral eflornithine treatment of late-stage human African trypanosomiasis

    Author : Mikael Boberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sleeping Sickness; Neglected Tropical Diseases; Enantiomers; Nonlinear Mixed Effects Modeling; Pharmacokinetics; Pharmacodynamics;

    Abstract : Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African trypanosomiasis (g-HAT) in the later disease stage when the parasites have infected the central nervous system. READ MORE