Search for dissertations about: "ttr"

Showing result 1 - 5 of 50 swedish dissertations containing the word ttr.

  2. 1. Selection of transthyretin amyloid inhibitors

    Author : Irina Iakovleva; Anders Olofsson; Göran Larsson; Bente Westergaard; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transthyretin; TTR; ATTR; TTR-stabilizing drugs; selectivity; medicinsk biokemi; Medical Biochemistry;

    Abstract : Amyloidosis is a group of clinical disorders caused by the aggregation of specific proteins into abnormal extracellular deposits. Today, 31 different proteins have been linked to amyloid diseases including transthyretin-related amyloidosis (ATTR). READ MORE

  4. 2. Enthymemes in Dialogue: A micro-rhetorical approach

    Author : Ellen Breitholtz; Göteborgs universitet; []
    Keywords : HUMANIORA; HUMANITIES; Topos; Enthymeme; ; TTR; Dialogue modelling; Non-monotonic reasoning; Accommodation; Micro-rhetoric; Gameboard semantics;

    Abstract : In dialogue we frequently present arguments which are based on commonly accepted non-logical inferences. In rhetorical theory, this type of argument is called an enthymeme, and a pattern of reasoning that it is based on is called a topos. The main purpose of this thesis is to investigate the role that enthymemes play in natural language dialogue. READ MORE

  5. 3. Anticoagulation treatment in patients with a mechanical heart valve

    Author : Bartosz Grzymala-Lubanski; Anders Själander; Peter J. Svensson; David Bergqvist; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mechanical heart valve; anticoagulation; warfarin; Time in Therapeutic Range TTR ; INR variability;

    Abstract : BackgroundEvery year about 2,500 patients in Sweden undergo surgery for heart valve disease, primarily in the aortic valve.  In contrast to the mitral valve, which can be repaired in 70% of the cases, the aortic valve is normally replaced by a mechanical or biological prosthesis. READ MORE

  6. 4. Warfarin treatment quality in stroke prevention

    Author : Fredrik Björck; Anders Själander; Peter Svensson; Per Wester; Christine Kremer; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anticoagulation; atrial fibrillation; complications; international normalized ratio INR variability; persistence; stroke; time in therapeutic range TTR ; treatment quality; warfarin; cardiovascular disease; hjärt- och kärlforskning;

    Abstract : BackgroundIschemic stroke is a serious condition often associated to presence of atrial fibrillation (AF). Use of anticoagulants for AF patients greatly reduces the risk of stroke. Warfarin is the most commonly used anticoagulant in Sweden. The aim of this thesis was to study the impact of warfarin treatment quality in Swedish stroke prevention. READ MORE

  7. 5. Molecular Aspects of Transthyretin Amyloid Disease

    Author : Karin Sörgjerd; Per Hammarström; Joel Buxbaum; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloid; apoptosis; BiP; chaperone; misfolding; oligomer; transthyretin; Biochemistry; Biokemi;

    Abstract : This thesis was made to get a deeper understanding of how chaperones interact with unstable, aggregation prone, misfolded proteins involved in human disease. Over the last two decades, there has been much focus on misfolding diseases within the fields of biochemistry and molecular biotechnology research. READ MORE