Search for dissertations about: "tumor driver genes"
Showing result 1 - 5 of 19 swedish dissertations containing the words tumor driver genes.
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1. Understanding Cancer Mutations by Genome Editing
Abstract : Mutational analyses of cancer genomes have identified novel candidate cancer genes with hitherto unknown function in cancer. To enable phenotyping of mutations in such genes, we have developed a scalable technology for gene knock-in and knock-out in human somatic cells based on recombination-mediated construct generation and a computational tool to design gene targeting constructs. READ MORE
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2. Computational exploration of cancer genomes
Abstract : Cancer evolves due to changes in DNA that give a cell an advantage at the expense of the remaining organism. These alterations range from individual base substitutions to broad losses or duplications of chromosomal material. READ MORE
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3. Comprehensive analysis of structural genomic alterations in cancer : Computational approaches for identifying cancer driver events
Abstract : The transformation of a normal cell into a cancer cell involves the accumulation of somatic DNA alterations that confer growth and survival advantages. These genomic alterations can be different in terms of pattern and size, comprising single nucleotide variants (SNVs), small insertions or deletions (indels), structural variations (SVs) or foreign DNA insertions such as viral DNA. READ MORE
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4. Inter and intra-tumor models of somatic evolution in cancer
Abstract : Cancer is a disease caused by the accumulation of somatic mutations in an evolutionary process. Mutations in so-called cancer driver genes provide the harboring cells with particular selective advantages and result in cancer progression. READ MORE
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5. Genetic Characterization of Bone and Soft Tissue Tumors
Abstract : Bone and soft tissue tumors (BSTT) constitute a heterogeneous group of neoplasms of mesenchymal and neuroectodermal origin. Although many BSTT are rare, it has become clear that BSTT are characterized by recurrent acquired chromosomal aberrations, and the general aim of this thesis have been to apply molecular genetic and molecular cytogenetic techniques to further characterize recurrent breakpoints and deletions, and to search for candidate target genes. READ MORE