Search for dissertations about: "tumor environment"

Showing result 1 - 5 of 104 swedish dissertations containing the words tumor environment.

2. 1. Targeting the prostate tumor microenvironment and vasculature : the role of castration, tumor-associated macrophages and pigment epithelium-derived factor

   Author : Sofia Halin; Anders Bergh; Pernilla Wikström; Stina Rudolfsson; Carl-Henrik Heldin; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; angiogenesis; castration therapy; microenvironment; stroma; tumor-associated macrophages; pigment epithelium-derived factor; PEDF; vasculature; Pathology; Patologi; patologi; Pathology;

   Abstract : BACKGROUND: Prostate cancer is the most common cancer among Swedish men. For patients with metastatic prostate cancer the standard therapy is castration, a treatment that initially provides symptomatic relief but unfortunately is not curative. New therapeutic targets for advanced prostate cancer are therefore needed. READ MORE

4. 2. The effect of the tumor environment on the anti-tumor immune response

   Author : W David Culp; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Cancer immunotherapy is the process of stimulating the host's immune system to kill cancer cells, and it is being investigated as adjuvant therapy to traditional cancer treatments such as, surgery, radiation therapy and chemotherapy. Two advantages of using immunotherapy are that it employs additional tumor killing strategies, and it often results in modest side effects for patients. READ MORE

5. 3. Activity of tumor-antigens in polyomavirus replication

   Author : Hongyun Li; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Tumor-Antigens; DNA Replication; Cell-cycle; Phosphorylation; J-domain; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

   Abstract : Polyomavirus replication needs an active cell environment, and the viral DNA replication is cell cycle regulated. Tumor antigens (T-antigens) of mouse polyomavirus, especially large T-antigen, are necessary for the replication. READ MORE

6. 4. CD40L Gene Therapy for Solid Tumors

   Author : Lina Liljenfeldt; Thomas Tötterman; Angelica Loskog; Sara Mangsbo; Evren Alici; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40L; adenovirus; tumor immunology; tumor microenvironment; immunotherapy; local immunotherapy; antigen presentation; Immunologi; Immunology;

   Abstract : Adenoviral CD40L gene therapy (AdCD40L) is a strong inducer of anti-tumor immune responses via its activation of dendritic cells (DCs). Activated DCs can in turn activate T cells, which are key players in an efficient anti-tumor response.This thesis includes three papers that focus on different aspects of AdCD40L gene therapy. READ MORE

7. 5. The Palaeopathology of Kirchberg : Evidence of Deficiency, Inflammatory and Tumorous Disease in a Medieval Rural Population in Hessia, Germany

   Author : Nikolaos Roumelis; Jan Storå; Michael Schultz; Pia Bennike; Stockholms universitet; []
   Keywords : HUMANIORA; HUMANITIES; Kirchberg; rural population; Middle Ages; palaeohistopathology; palaeopathology; microscopy; diagnosis; health; inflammatory disease; tumorous disease; micrometastases; deficiency disease; environment.; Archaeology; Arkeologi; osteoarkeologi; Osteoarchaeology;

   Abstract : This study investigates the interaction of disease processes, disease and environment, female and male health as well as health and ageing in a medieval rural village population. For this purpose multiple skeletal indicators of health have been studied, including deficiency, inflammatory, infectious and tumorous disease. READ MORE