Search for dissertations about: "tumor evolution"
Showing result 1 - 5 of 50 swedish dissertations containing the words tumor evolution.
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1. Cancer Evolution under Chemotherapy Treatment
Abstract : Background: Chemotherapy resistance is a critical issue in oncology, being responsible for the majority of deaths in modern cancer care. My PhD work has focused on two cancer types where such drug resistance is a major clinical issue: epithelial ovarian cancer (EOC) and Wilms tumor (WT). READ MORE
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2. Inter and intra-tumor models of somatic evolution in cancer
Abstract : Cancer is a disease caused by the accumulation of somatic mutations in an evolutionary process. Mutations in so-called cancer driver genes provide the harboring cells with particular selective advantages and result in cancer progression. READ MORE
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3. Massively Parallel Sequencing of Gene Fusion-Associated Sarcomas
Abstract : .... READ MORE
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4. Affibody molecules targeting the epidermal growth factor receptor for tumor imaging applications
Abstract : Tumor targeting and molecular imaging of protein markers specific for or overexpressed in tumors can add useful information in deciding upon treatment and assessing the response to treatment for a cancer patient. The epidermal growth factor receptor (EGFR) is one such tumor-associated receptor, which expression is abnormal or upregulated in various cancers and associated with a poor patient prognosis. READ MORE
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5. Staphylococcal surface display in directed evolution
Abstract : Engineered affinity proteins have together with naturally derived antibodies becomeindispensable tools in many areas of life-science and with the increasing number ofapplications, the need for high-throughput methods for generation of such different affinityproteins is evident. Today, combinatorial protein engineering is the most successful strategy toisolate novel non-immunoglobulin affinity proteins. READ MORE