Search for dissertations about: "tumor necrosis factor-α"

Showing result 11 - 15 of 38 swedish dissertations containing the words tumor necrosis factor-α.

  2. 11. Calcium metabolism and cytokines in critical illness

    Author : Fredrik Carlstedt; Uppsala universitet; []
    Keywords : Medical sciences; calcium; critical illness; hemodynamics; hypocalcemia; IL-6; mortality; TNF-alpha; severity of disease; sepsis; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Hypocalcemia is a common finding in critically ill patients, particularly in those with sepsis, and has been found to be associated with increased mortality. The pathogenesis of this altered calcium metabolism is unknown and the effects of calcium supplementation are poorly investigated. READ MORE

  4. 12. Experimental Studies Aiming to Prevent Type 1 Diabetes Mellitus

    Author : Tobias Rydgren; Stellan Sandler; Nils Welsh; Adrian Bone; Uppsala universitet; []
    Keywords : Cell biology; Diabetes; Interleukin-1 trap; Simvastatin; Nitric oxide synthase; Cytokine; Pancreatic islet; Streptozotocin; Transplantation; Cellbiologi;

    Abstract : Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which T-cells and macrophages invade the islets of Langerhans and selectively destroy the insulin producing β-cells, either directly or through the secretion of e.g. cytokines and nitric oxide (NO). This thesis has studied possible strategies to prevent T1DM. READ MORE

  5. 13. Molecular Mechanisms in Endothelial Cell Differentiation

    Author : Emma Rennel; Pär Gerwins; Lena Claesson-Welsh; Ian Zachary; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; angiogenesis; FGF-2; VEGF-A; signal transduction; in vitro angiogenesis assay; immortalized brain endothelial cells; H-Ras; tetracycline-regulated gene expression; microarray; telomerase immortalized human microvascular endothelial cells; differentiation; Patologi; Pathology; Patologi;

    Abstract : Angiogenesis is the formation of new blood vessels from the pre-existing blood vessels. Blood vessels are composed of endothelial cells and supporting musculature. Angiogenesis is regulated by numerous soluble ligands and by cell-matrix interactions. READ MORE

  6. 14. Studies on 15-lipoxygenase in dendritic cells and leukotriene receptors in Hodgkin lymphoma

    Author : Frida Schain; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Classical Hodgkin lymphoma (cHL) is histologically characterized by a minority of malignant cells, the so-called Hodgkin-Reed Sternberg (H-RS) cells, surrounded by inflammatory cells such as T lymphocytes, eosinophils, macrophages and mast cells. It is generally believed that various molecules released by the H-RS cells are of major importance in the pathophysiology of cHL. READ MORE

  7. 15. Vascular Interactions in Innate Immunity and Immunothrombosis: : Models of Endothelial Protection

    Author : Sofia Nordling; Peetra Magnusson; Paul Kubes; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endothelial cells; Thrombosis; Innate immunity; Immunothrombosis; Thromboinflammation; Immunologi; Immunology;

    Abstract : The phenomenon known as immunothrombosis has garnered increased attention over the last few years. Much work has been done to characterize the cross talk between hemostasis and the innate immune system. READ MORE