Search for dissertations about: "tumor necrosis factor"

Showing result 16 - 20 of 217 swedish dissertations containing the words tumor necrosis factor.

  2. 16. Oxygen delivery and mitochondrial dysfunction as assessed by microdialysis during interventions in experimental sepsis

    Author : Magnus von Seth; Lipscey Miklós; Jan Sjölin; Mats Eriksson; Jukka Takala; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; animal models; microdialysis; endotoxin; Escherichia coli; tigecycline; doxycycline; albumins; capillary leak syndrome; lactic acid; oxygen delivery; multiple organ failure; mitochondria; tumor necrosis factor alpha; interleukin-6; cyanides; ouabain; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

    Abstract : Early administration of broad-spectrum antibiotics is the first goal in sepsis treatment. Besides from bacteriostatic/bactericidal effects, some antibiotics may also modify the host´s response to infection. The novel antibiotic tigecycline may exert such properties; however, this property has not been evaluated in large-animal trials. READ MORE

  4. 17. Aspects on inflammation and cardiovascular comorbidity in rheumatoid arthritis

    Author : Lotta Ljung; Solbritt Rantapää-Dahlqvist; Johan Askling; Piet van Riel; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; co-morbidity; cardiovascular disease; atherosclerosis; acute coronary syndromes; adipokines; adipose tissue; tumor necrosis factor inhibition;

    Abstract : There is an increased risk for cardiovascular (CV) comorbidity among patients with rheumatoid arthritis (RA), with premature atherosclerosis, and a higher incidence of CV events, compared with the general population. Disease related factors add to the CV risk, and interact with the traditional CV risk factors. READ MORE

  5. 18. Inflammation and lifestyle in cardiovascular medicine

    Author : Jonas Andersson; Kurt Boman; Jan-Håkan Jansson; Lars Johansson; Joep Perk; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C-reactive protein; cardiovascular disease; stroke; atrial fibrillation; lifestyle; interleukin-6; tumor necrosis factor-α; exercise; physical activity; obesity; the metabolic syndrome; fibrinolysis; Cardiology; Kardiologi; kardiologi; Cardiology;

    Abstract : Despite major advances in the treatment and prevention of atherosclerosis the last several decades, cardiovascular disease still accounts for the majority of deaths in Sweden. With the population getting older, more obese and with rising numbers of diabetics, the cardiovascular disease burden may increase further in the future. READ MORE

  6. 19. Exploration of Conditions Affecting Cytokine Production in Experimental Type 1 Diabetes Mellitus

    Author : Lina Thorvaldson; Stellan Sandler; Michael Welsh; Maria Holstad; Maria Faresjö; Uppsala universitet; []
    Keywords : Cell biology; Cytokine; Diabetes; Tumor necrosis factor-α; Interferon-γ; Interleukin-4; Interleukin-10; Transplantation; Pancreatic islet; Glucose; Regulatory T cell; Cellbiologi;

    Abstract : Cytokines are soluble signalling mediators within the immune system, and have been shown to be of importance in the development of type 1 diabetes (T1D). This thesis studied the production of cytokines in experimental models of T1D and during transplantation of insulin-producing islets of Langerhans. READ MORE

  7. 20. Prognostic factors in soft tissue sarcoma. Tissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence

    Author : Jacob Engellau; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; growth pattern; time-dependence; P-glycoprotein Pgp ; CD44; β-catenin; cyclin A; bcl-2; p53; Ki-67; immunohistochemistry IHC ; whole-tumor sections; tissue microarray TMA ; Soft tissue sarcoma; prognostic factors; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

    Abstract : In adult soft tissue sarcoma (STS) of the extremities and trunk wall, improved prognostic factors are needed to identify patients at high-risk for metastasis. Various factors are included in the many prognostic systems currently in use and the prognostic value of immunohistochemical (IHC) expression of biological markers is unclear. READ MORE