Search for dissertations about: "tumor rejection."

Showing result 1 - 5 of 34 swedish dissertations containing the words tumor rejection..

2. 1. Immuno Gene Therapy of Rat Brain Tumors with interferon-gamma transfected glioma cells

   Author : Edward Visse; Neurokirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; transplantation; serologi; Immunologi; Immunotherapy; Rat brain tumor; Interferon-gamma; isograft rejection; tumor infiltrating lymphocytes; Immunization; Immunology; serology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Abstract : Immunotherapy is a new promising approach in cancer treatment. In the future, it will hopefully offer an alternative to existing brain tumors treatments, which are unable to cure. We have established an experimental, low immunogenic, brain tumor model in the rat. READ MORE

4. 2. Inflammation in Parkinson’s Disease and Experimental Neural Transplantation. Role of Cellular Responses, Cytokines and Immunosuppression in Graft Rejection

   Author : Bilal Mirza; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; graft rejection.; pig; human; rat; xenogeneic; allogeneic; syngeneic; transplantation immunology; immunosuppression; cytokines; neural transplantation; Parkinson’s Disease; inflammation; neurodegeneration; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Abstract : Abstract: Parkinson’s disease (PD) is a common neurodegenerative disorder. There is no proven protection, but many treatments can partially improve symptoms. The disease is caused by monogenetic mechanisms in very few cases, but for the majority of patients the etiology is unknown. READ MORE

5. 3. Immunity and immunosuppression in the tumor-host interaction

   Author : Max Petersson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Tumors; MHC class 1; natural processed peptides; T cells; NK cells; IFN-[gamma]; IL-10; TAP;

   Abstract : With the advent of new methods in molecular biology and in peptide isolation, a number of tumor-associated antigens and their epitopes have been identified and characterized. However, tumors often grow progressively evolving different mechanisms of immune escape, resulting in resistance to MHC class I-restricted tumor-specific T cells. READ MORE

6. 4. Radioimmunotherapy in an Immunocompetent Tumor Model utilizing a 177Lu-mAb

   Author : Erika Elgström; Tumörmikromiljö; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Radioimmunotherapy (RIT) is a therapeutic strategy in which radionuclides are conjugated to monoclonal antibodies that bind to tumor-associated antigens in the tumor, so that the decay of the radionuclide takes place inside the tumor. The aim of the research presented in this thesis was to investigate the effects of RIT (utilizing the radioconjugated antibody 177Lu-BR96) on an inoculated tumor and the development of metastases. READ MORE

7. 5. Involvement of T lymphocyte subsets in the rejection of murine tumors by syngeneic or autologous hosts

   Author : Tao Wen; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The aim of this thesis is to study the requirement of CD4+ and CD8+ T Iymphocyte subset, CD28 costimulatory molecule and p56kk for the rejection of syngeneic tumor grafts, and the autochthonous tumors induced by Moloney murine sarcoma virus. It also addresses the role of CD4+ and CD8+ T subsets with regard to the polyomavirus persistence and tumor development. READ MORE