Search for dissertations about: "tumor vaccine"
Showing result 1 - 5 of 44 swedish dissertations containing the words tumor vaccine.
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1. Development of a Cancer Vaccine Targeting Tumor Blood Vessels
Abstract : A treatment strategy for cancer is the suppression of tumor growth by directing an immune response to the tumor vessels, which will destroy the tissue.In this thesis we describe the development of a vaccine that targets antigens expressed around angiogenic vasculature in most solid tumors. READ MORE
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2. Therapeutic Cancer Vaccines Targeting Molecules Associated with Tumor Angiogenesis
Abstract : Induction of an endogenous antibody response by therapeutic vaccination could provide an alternative to cost-intensive monoclonal antibody-based treatments for cancer. Since the target of a cancer vaccine will most likely be a self-antigen, self-tolerance of the immune system must be circumvented. READ MORE
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3. Vaccine Therapy of Colorectal Cancer Patients with Tumor Associated Antigens
Abstract : In this thesis, two different vaccines were evaluated as adjuvant therapy for patients with colorectal cancer. The ability of the two candidate vaccines to generate antigen-specific cellular and humoral responses, respectively, was studied. READ MORE
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4. Tumor gene therapy using Semliki forest virus replicons
Abstract : A major challenge in cancer research is to design effective vaccines that can break immunological tolerance to tumor antigens. Over the past ten years several immunotherapeutic strategies aimed at modulating the patient's immune response to fight cancer have been tested in clinical trials. READ MORE
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5. Studies on persistent polyomavirus infection in relation to tumor development and options for vaccine and gene therapy
Abstract : Polyomavirus is a small DNA virus capable of inducing tumors in mice with a defective or an immature immune system. The importance of T-cells in prevention of polyoma-induced tumor development has previously been shown. In this thesis, we wished to elucidate the role of humoral immunity with regard to polyomavirus persistence and tumor development. READ MORE