Search for dissertations about: "tumor-infiltrating lymphocytes"

Showing result 1 - 5 of 35 swedish dissertations containing the words tumor-infiltrating lymphocytes.

2. 1. Immuno Gene Therapy of Rat Brain Tumors with interferon-gamma transfected glioma cells

   Author : Edward Visse; Neurokirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; transplantation; serologi; Immunologi; Immunotherapy; Rat brain tumor; Interferon-gamma; isograft rejection; tumor infiltrating lymphocytes; Immunization; Immunology; serology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Abstract : Immunotherapy is a new promising approach in cancer treatment. In the future, it will hopefully offer an alternative to existing brain tumors treatments, which are unable to cure. We have established an experimental, low immunogenic, brain tumor model in the rat. READ MORE

4. 2. Novel immunotherapies for metastatic melanoma - from mouse models towards clinical trials

   Author : Elin Forsberg; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic melanoma; uveal melanoma; patient-derived xenograft; immune-humanized mouse model; immunotherapy; adoptive T cell therapy; tumor-infiltrating lymphocytes; chimeric antigen receptor T CAR-T cells;

   Abstract : Immunotherapies including checkpoint blockade and adoptive T cell transfer (ACT) show great promise for the treatment of melanoma, with long-term effects in some patients. However, around half of the patients with metastatic malignant melanoma will not be cured with available therapies today, and these patients require other treatment strategies. READ MORE

5. 3. The use of immunological biomarkers to improve individualization of postoperative radiotherapy in breast cancer

   Author : Axel Stenmark Tullberg; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor-infiltrating lymphocytes; CD8; FOXP3; Radiotherapy; Breast cancer;

   Abstract : Radiotherapy (RT) forms the cornerstone of most curative breast cancer treatment due to its well-established risk-reducing effect on local recurrences at the population level. However, there is heterogeneity regarding treatment benefits at the individual level, and research currently aims to better tailor treatment decisions based on tumor biology. READ MORE

6. 4. Inflammatory Cells and Mediators in the Tumor Microenvironment of Breast Cancer

   Author : Roni Allaoui; Malmö Cancerimmunologi; []
   Keywords : Breast cancer; tumor stroma; cancer-associated fibroblasts; DAMP; inflammatory mediators; myeloid-derived supressor cells; toll-like receptors; triple-negative breast cancer; tumor infiltrating lymphocytes; tumor microenvironment;

   Abstract : .... READ MORE

7. 5. Tumor-infiltrating lymphocytes and the PD-L1/PD-1 signaling axis in breast cancer : biology and clinical implications

   Author : Ioannis Zerdes; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Cancer immunotherapy and especially immune checkpoint blockade therapy has revolutionized cancer treatment in many tumor types including breast cancer (BC). The expression and specific role of Programmed Death-1 (PD-1)/Programmed Death-Ligand 1 (PD-L1) signaling axis, immune-related gene signatures and immune cell subpopulations needs to be fully elucidated while the identification of prognostic and predictive biomarkers in BC is of utmost importance. READ MORE