Search for dissertations about: "tumorigenesis"

Showing result 11 - 15 of 218 swedish dissertations containing the word tumorigenesis.

  2. 11. Examining the role of metabolism in Myc-driven tumorigenesis

    Author : Tacha Zi Plym Forshell; Jonas Nilsson; Mattias Belting; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cancer; Myc; metabolism; polyamines; spermidine synthase; glycolysis; lactate dehydrogenase; serine metabolism; Phgdh; folate metabolism; Shmt; Pim kinase; Pim-3 Kinase; Molecular biology; Molekylärbiologi;

    Abstract : Myc transcriptionally regulates genes involved in processes such as cell proliferation, metabolism, differentiation, and angiogenesis.  MYC expression is deregulated in many types of human cancer; therefore discovering the mechanisms behind MYCs role in tumorigenesis is essential. READ MORE

  4. 12. Phospholipase C β3, and its role in endocrine tumorigenesis

    Author : Peter Stålberg; Uppsala universitet; []
    Keywords : Medical sciences; Phospholipase C beta 3; endocrine tumors; in situ hybridization; transfection; tumorsuppressor; differential expression; gene targeting; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : The Phospholipase C β3 (PLCB3) gene is located on chromosome 11q13, in the vicinity of theMultiple Endocrine Neoplasia type 1 (MEN1) suppressor gene. PLCB3 has been implicated inendocrine tumorigenesis based on findings of low expression in endocrine tumors, and the probableexistence of other suppressor genes located at 11q13. READ MORE

  5. 13. Activation of the novel PDGFS by plasminogen activators in tumorigenesis

    Author : Monika Ehnman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Members of the platelet-derived growth factor (PDGF) family are mitogens for cells of a mesenchymal origin and have important functions both during development and in the adult. Their role in developmental processes has been extensively investigated by methodical targeted gene inactivations, revealing critical involvement in microvascular pericyte recruitment, neural crest development and alveogenesis. READ MORE

  6. 14. The cell cycle regulators p18Ink4c and p19Ink4d : in vivo studies of their roles in tumorigenesis and development

    Author : Lisa Nilsson; Olle Heby; Martine Roussel; Klas Wiman; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi;

    Abstract : Progression through the G1, S, G2 and M phases of the cell cycle is controlled by cyclin-dependent kinases (Cdks) and cyclins. These proteins form active Cdk:cyclin complexes that phosphorylate specific substrates. READ MORE

  7. 15. Studies of VEGF-B and novel PDGFs in tumorigenesis and angiogenesis

    Author : Hong Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The family of VEGF/PDGF growth factors and their receptors are important regulators of tumorigenesis and angiogenesis. VEGFs have been shown to play important roles in development of both blood and lymphatic vessels by effect on endothelia cells. READ MORE