Search for dissertations about: "tumorigenesis"

Showing result 16 - 20 of 218 swedish dissertations containing the word tumorigenesis.

  2. 16. New Insights in Genetic and Epigenetic Mechanisms Involved in Parathyroid Tumorigenesis

    Author : Lee Starker; Peyman Björklund; Barbra Miller; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parathyroid; yumorigenesis; mutation; exome sequencing;

    Abstract : Primary hyperparathyroidism (pHPT) is a pathology associated with one or multiple hyperfunctioning parathyroid glands.  The disease prevalence occurs in roughly 1-2% of the population primarily post-menopausal women.  The molecular pathology of the disease is poorly understood. READ MORE

  4. 17. Modeling and investigations of high-grade glioma to understand tumorigenesis and heterogeneity

    Author : Nagaprathyusha Maturi; Lene Uhrbom; Helena Carén; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioblastoma; diffuse pediatric-type high-grade glioma; cell of origin; heterogeneity; serum culture; glioblastoma stem cell; chromatin accessibility; cross-species conservation; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : Glioblastoma (GBM) is the most common primary malignant brain tumor. As per 2021 WHO classification, the corresponding diagnosis in children is called diffuse pediatric-type high-grade glioma (pHGG). In both cases tumors are histone 3 (H3) and isocitrate dehydrogenase 1/2 (IDH1/2) wildtype (wt). READ MORE

  5. 18. Vascular development and safeguard mechanisms against tumorigenesis : oncogene-induced apoptosis and cellular senescence

    Author : Eduar Hejll; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Angiogenesis;

    Abstract : Angiogenesis, apoptosis and senescence are all cellular processes that have an impact on tumor development. Angiogenesis or the new vessel formation from pre-existing ones is known to be required for invasive tumor growth and metastasis. READ MORE

  6. 19. The role of suppressor of fused in development and tumorigenesis in the mouse

    Author : Karin Heby-Henricson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Embryonic development is a process that involves a number of evolutionarily well-conserved signaling cascades, including the hedgehog pathway. Mutations in components of this pathway have been identified in certain developmental disorders, and in many different kinds of cancers. READ MORE

  7. 20. Molecular aspects of parathyroid tumorigenesis : with focus on parafibromin and the Wnt pathway

    Author : Christofer Juhlin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Primary hyperparathyroidism (PHPT) denotes the tumorous enlargement of one or several parathyroid glands and constitutes a common disorder, particularly pronounced among postmenopausal women. PHPT patients display hypercalcemia as a consequence of parathyroid hormone hypersecretion, and the symptomatology is habitually based on this metabolic aberrancy. READ MORE