Search for dissertations about: "tumorigenicity"

Showing result 1 - 5 of 17 swedish dissertations containing the word tumorigenicity.

  2. 1. Nasopharyngeal carcinoma and Epstein-Barr virus

    Author : Li-Fu Hu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NPC; EBV; EBNAs; LMPI; LMP2; Tumorigenicity; Immunogenicity;

    Abstract : Nasopharyngeal carcinoma (NPC) is the most common tumor in southern China and also quite frequent among the Eskimos and in Alaska. NPC is invariably associated with Epstein-Barr virus (EBV). READ MORE

  4. 2. Interplay Between Cell of Origin and Oncogenic Activation in Glioma

    Author : Yiwen Jiang; Lene Uhrbom; Anders Persson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; PDGF; cell of origin; Sox5; glioma initiating cells; Oncology; Onkologi;

    Abstract : Glioma is the most frequent primary tumor of the central nervous system. By using the RCAS/tv-a mouse glioma model, we have studied mechanisms controlling glioma development and the effect of cell of origin on these processes.SOX5 was identified as a brain tumor locus in a retroviral insertional mutagenesis screen of PDGF-B induced mouse gliomas. READ MORE

  5. 3. Molecular and Cellular Complexity of Glioma : Highlights on the Double-Edged-Sword of Infiltration Versus Proliferation and the Involvement of T Cells

    Author : Demet Çağlayan; Bengt Westermark; Maria Ferletta; Ana Martin-Villalba; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; Sox2; Sox21; Snail; Bone morphogenetic protein; Sleeping Beauty; Gliomatosis Cerebri; T lymphocytes; T regulatory lymphocytes; Oncology; Onkologi; Biology; Biologi;

    Abstract : Glioblastoma multiforme (GBM), the most common and malignant brain tumor, is characterized by high molecular and cellular heterogeneity within and among tumors. Parameters such as invasive growth, infiltration of immune cells and endothelial proliferation contribute in a systemic manner to maintain the malignancy. READ MORE

  6. 4. Scalable, safe and GMP-compatible production of embryonic stem cell derived retinal pigment epithelial cells

    Author : Sara Padrell Sánchez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Regenerative medicine is an exponentially growing field that aims to regenerate a lost function, cell type or tissue due to damage, ageing or disease. Currently, more than 30,000 gene- and cell-based therapies have been or are being tested in clinical trials. READ MORE

  7. 5. Endometrial regeneration : unraveling the mysteries of the stroma

    Author : Suzanna Queckbörner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The healthy endometrium has the unique capacity of shedding and regenerating its functional layer once every menstrual cycle, under the regulation of hormones, progenitor cell populations and inflammatory mediators. Thanks to this meticulously timed cycle the uterus is regularly renewed in preparation for blastocyst implantation. READ MORE