Search for dissertations about: "tumour targeting"

Showing result 1 - 5 of 64 swedish dissertations containing the words tumour targeting.

  1. 1. Tumour Targeting Using Radiolabelled EGF Conjugates Preclinical Studies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Åsa Liljegren Sundberg; Jörgen Carlsson; Lars Gedda; Vladimir Tolmachev; Erik Blomquist; Gregory P. Adams; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; targeting; tumour; EGF; radionuclide; gefitinib; Iressa; ZD1839; glioma; therapy; diagnostics; Strålningsvetenskap; MEDICINE Physiology and pharmacology Radiological research Radiation biology; MEDICIN Fysiologi och farmakologi Radiologisk forskning Strålningsbiologi;

    Abstract : Tumour targeted radiotherapy is an appealing approach for treatment of disseminated tumour cells. A targeting agent that specifically binds to a structure on tumour cells is then used to transport therapeutically relevant radionuclides. The epidermal growth factor receptor, EGFR, is overexpressed on tumour cells in several malignancies, e.g. READ MORE

  2. 2. Two-Step Targeting for Effective Radionuclide Therapy Preclinical Evaluation of 125I-labelled Anthracycline Delivered by Tumour Targeting Liposomes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Amelie Fondell; Lars Gedda; Detlef Gabel; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radionuclide; Auger electrons; liposomes; targeting; tumour therapy; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : For the treatment of cancer, Auger-electron emitting radionuclides are strongly dependent on their close proximity to DNA to utilize the local therapeutic potential of the Auger electrons. This thesis investigates a two-step targeting approach that uses targeting liposomes for the delivery of an Auger-electron emitter, 125I, coupled to a DNA-binding compound, Comp1, to the tumour-cell DNA. READ MORE

  3. 3. Aspects of Tumour Targeting Preclinical Studies on Human Malignant Cells in vitro

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Maria Dahlström Wester; Annelie Lindström; Åke Wasteson; Lars Gedda; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Abstract : Exclusive eradication of tumour cells causing minimal damage to healthy tissue, a concept referred to as targeting, is an interesting approach to improve the outcome for patients afflicted with cancer.The general aim of this thesis was to highlighten aspects that could be of importance in developing novel treatment regimens based on specific targeting of tumour cells. READ MORE

  4. 4. Antibody-Based Radionuclide Targeting for Diagnostics and Therapy Preclinical Studies on Head and Neck Cancer

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Marika Nestor; Matti Anniko; Jörgen Carlsson; Hans Lundqvist; Vladimir Tolmachev; Matthew Robinson; [2006]
    Keywords : Otorhinolaryngology; antibodies; radionuclide targeting; tumour targeting; therapy; diagnostics; immuno-PET; head and neck squamous cell carcinoma; Otorhinolaryngologi;

    Abstract : Antibody-based targeting techniques play an increasingly important role in cancer research. By targeting a structure that is abundant in tumour cells, but rare in healthy tissues, an antibody can mediate the delivery of radioactivity specifically to tumour cells in the body. READ MORE

  5. 5. Dextran conjugates for tumour targeting : synthesis and characterisation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anders R. Holmberg; [1995]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Abstract : .... READ MORE