Search for dissertations about: "tumour targeting"

Showing result 16 - 20 of 80 swedish dissertations containing the words tumour targeting.

  2. 16. Indirect Radiohalogenation of Targeting Proteins : Labelling Chemistry and Biological Characterisation

    Author : Anna Orlova; Hans Lundqvist; Jörgen Carlsson; Lars Gedda; Jacek Capala; D.Scott Wilbur; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; radiohalogenation; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Abstract : In about half of all newly diagnosed cancer cases, conventional treatment is not adequately curative, mainly due to the failure of conventional techniques to find and kill residual cells and metastases, which might consist of only a few malignant cells, without causing unacceptable complications to healthy tissue. To solve the problem a more selective delivery of cytotoxic substances to tumour cells is needed. READ MORE

  4. 17. Cellular Studies of HER-family Specific Affibody Molecules

    Author : Lovisa Göstring; Lars Gedda; Jörgen Carlsson; Fredrik Frejd; Håkan Hedman; Uppsala universitet; []
    Keywords : EGFR; HER2; HER3; Affibody; internalisation; tumour targeting; MEDICINE; MEDICIN;

    Abstract : The human epidermal growth-factor like receptor (HER) family of receptor tyrosine kinases are important targets for cancer therapy. The family consists of four members - EGFR, HER2, HER3 and HER4 - that normally transfer stimulatory signals from extracellular growth factors to the intracellular signalling network. READ MORE

  5. 18. Targeting Myc-driven tumours - BETing on ATR

    Author : Somsundar Veppil Muralidharan; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cancer arises from loss of function of tumour suppressors and/or gain of function mutations in proto-oncogenes that disrupt the delicate balance required for homeostatic cell division, resulting in uncontrolled cell proliferation. Oncogenic transformation of multifaceted proto-oncogene - transcription factor - MYC can give rise to cancers and it is found to be deregulated in more than 70% of the tumours. READ MORE

  6. 19. Functional studies of the Sro yeast homologues of the Drosophila lethal (2) giant larvae tumor suppressor genes

    Author : Ingrid Wadskog; Jönköping University; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ion homeostasis; salt stress; exocytosis; protein targeting; apaptosis; l 2 gl tumour suppressor; S. cerevisiae; SRO7; ENA1; Microbiology; Mikrobiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : .... READ MORE

  7. 20. Specific targeting of antigen-presenting cells for immunotherapy

    Author : Sissela Broos; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Immunotherapy, which involves strategies to activate, enhance or redirect immune responses to achieve long-lasting immunity, has the potential to play an important role in the treatment of a variety of diseases. This thesis, based on four original papers, highlights different approaches to modulate immune responses by specific targeting of antigen-presenting cells. READ MORE