Search for dissertations about: "two-state folding"
Showing result 1 - 5 of 13 swedish dissertations containing the words two-state folding.
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1. Physical Modeling of Protein Folding
Abstract : Sequence-based models for protein folding are developed and tested on peptides with both alpha- and beta-structure, and on small three-helix-bundle proteins. The interaction potentials of the models are minimalistic and based mainly on hydrogen bonding and effective hydrophobicity forces. READ MORE
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2. Protein Folding Studied by Site Directed Mutagenesis
Abstract : The N-terminal RNA binding domain of U1A has been shown to fold in a two-state process without accumulating any intermediates. U1A has a symmetrically curved chevron plot which seems to result mainly from changes of the transition state. READ MORE
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3. Statistical Physics of Protein Folding and Aggregation
Abstract : The mechanisms of protein folding and aggregation are investigated by computer simulations of all-atom and reduced models with sequence-based potentials. A quasi local Monte Carlo update is developed in order to efficiently sample proteins in the folded phase. READ MORE
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4. The birth and growth of the protein folding nucleus : Studies of protein folding focused on critical contacts, topology and ionic interactions
Abstract : Proteins are among the most complex molecules in the cell and they play a major role in life itself. The complexity is not restricted to just structure and function, but also embraces the protein folding reaction. READ MORE
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5. Folding of the Ribosomal protein S6 : The role of sequence connectivity, overlapping foldons, and parallel pathways
Abstract : To investigate how protein folding is affected by sequence connectivity five topological variants of the ribosomal protein S6 were constructed through circular permutation. In these constructs, the chain connectivity (i.e. the order of secondary-structure elements) is changed without changing the native-state topology. READ MORE