Search for dissertations about: "type 1 clinical trials"

Showing result 21 - 25 of 85 swedish dissertations containing the words type 1 clinical trials.

  2. 21. Disability and physical exercise in adults with myotonic dystrophy type 1

    Author : Marie Kierkegaard; Karolinska Institutet; Karolinska Institutet; []
    Keywords : classification;

    Abstract : Background: Myotonic dystrophy type 1(DM1) is an inherited, slowly progressive, multi-system disease. There is no overall picture of its effect in individuals, and there is a lack of scientific evidence to support recommendations on physical exercise. READ MORE

  4. 22. Development of Mouse Models and Gene Therapy for Gaucher Disease

    Author : Ida Berglin-Enquist; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Gaucher disease (GD) patients cannot metabolize glycosphingolipids properly due to deficiency of the enzyme glucosylceramidase (GCase). The lack of animal model for GD has hindered comprehensive investigation of disease mechanisms and also the development of curative treatment strategies such as hematopoietic stem cell (HSC) targeted gene therapy. READ MORE

  5. 23. Herpesvirus-induced glycans: Selectin ligands and related structures on the surface of the infected cell

    Author : Rickard Nordén; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Glycobiology; Herpesvirus; Selectin ligand;

    Abstract : Human herpesviruses are usually acquired early in life and are widely distributed in the population. A common feature of all human herpesviruses is that they persist in the host after the primary infection. READ MORE

  6. 24. Self-Management of Urinary Incontinence Using eHealth : clinically relevant improvement, treatment effect and factors associated with success

    Author : Emma Nyström; Eva Samuelsson; Malin Sjöström; Guri Rørtveit; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urinary incontinence; pelvic floor muscle training; eHealth; self-management; quality of life; randomised controlled trial; Family Medicine; allmänmedicin;

    Abstract : Background: Urinary incontinence is common among women, with prevalence most often reported to be between 25% and 45%. The most common type is stress urinary incontinence (SUI), defined as leakage upon exertion. First-line treatment includes pelvic floor muscle training (PFMT) and lifestyle advice. READ MORE

  7. 25. Palladium(0)-Catalyzed Spirocyclization and Carbonylation Reactions : Ligands Targeting the Angiotensin II Type 2 Receptor

    Author : Jens Lindman; Mats Larhed; Johan Gising; Christian Sköld; Alessandra Tolomelli; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium catalysis; Mizoroki-Heck reaction; spiroindolines; spirooxindoles; amino acids; carbonylation; angiotensin II type 2 receptor; AT2R ligands; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Palladium(0)-catalyzed chemistry represents one of the most important methods for the construction of carbon-carbon bonds, which are ubiquitous in organic compounds. The first part of this thesis describes the palladium(0)-catalyzed diastereoselective Mizoroki-Heck reaction of Vince lactam-derived precursors for the formation of spiroindolines (paper I) and spirooxindoles, which are scaffolds present in several natural products with interesting biological activity. READ MORE