Search for dissertations about: "type 2 diabetes mellitus"

Showing result 16 - 20 of 234 swedish dissertations containing the words type 2 diabetes mellitus.

  2. 16. Prevention of type 2 diabetes modeling the cost-effectiveness of diabetes prevention

    University dissertation from Umeå : Umeå University

    Author : Anne Neumann; Umeå universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes mellitus; prevention; health economics; Markov modeling; risk equations; health-related quality of life; lifestyle modification; pre-diabetic states; cost-effectiveness; Västerbotten Intervention Programme;

    Abstract : Background: Diabetes is a common and costly disease that is expected to continue even to grow in prevalence and health expenditures over the coming decades. Type 2 diabetes is the most common diabetes type and is characterized by insulin resistance and relative insulin deficiency. READ MORE

  4. 17. Candidate Genes for Late Diabetic Complications

    University dissertation from Endocrinology

    Author : Eero Lindholm; Lund University.; Lunds universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF; sekretion; LTA; Endocrinology; nephropathy; diabetes mellitus; retinopathy; neuropathy; genetic; UCP; diabetologi; AGER; MHc2TA; HLA-DQB1; Endokrinologi; secreting systems; diabetology;

    Abstract : Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The new WHO criteria for classification of diabetes takes into account also clinical stages dividing the diabetic patients into noninsulin requiring (NIR), insulin requiring for control (IRC) and insulin requiring for survival (IRS) subgroups. READ MORE

  5. 18. Beta Cell Function: from Human Genetics to Animal Models

    University dissertation from Lund University

    Author : Martins Kalis; Lund University.; Lunds universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; animal model; Dicer1; genetics; genetic association; single nucleotide polymorphism; SNP; INS-1E; AAT; FOXP3; beta cell function; insulin secretion; FFAR1; insulin; T2D; glucose; T1D;

    Abstract : Beta cell function is an important factor in the development of both Type 1 (T1D) and Type 2 (T2D) diabetes mellitus. T1D is characterized by a primary defect in insulin secretion due to the immune-mediated beta cell destruction, however, the more common T2D beside insulin resistance also include impaired beta cell function as a consequence to abnormal glucose homeostasis. READ MORE

  6. 19. Glucagon Counter-Regulation to Hypoglycemia During Incretin-Based Therapy

    University dissertation from Lund University: Faculty of Medicine

    Author : Johan Farngren; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Incretin; DPP-4; GLP-1; Glucagon; Hypoglycemia; Diabetes;

    Abstract : AbstractIncretin-based therapy is associated with low risk of hypoglycemia in type 2 diabetes mellitus (T2DM) possibly due to its glucose-dependency in stimulating insulin secretion and a sustained glucagon response during hypoglycemia. This is of special relevance when it is combined with insulin or given to elderly patients since both insulin therapy and high age are associated with impaired glucagon counter-regulation. READ MORE

  7. 20. Semi-mechanistic models of glucose homeostasis and disease progression in type 2 diabetes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Steve Choy; Uppsala universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; glucose homeostasis; insulin; type 2 diabetes; obesity; weight; visceral adipose tissue; HbA1c; non-linear mixed effects; modelling; disease progression; ZDSD rats; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by consistently high blood glucose, resulting from a combination of insulin resistance and reduced capacity of β-cells to secret insulin. While the exact causes of T2DM is yet unknown, obesity is known to be a major risk factor as well as co-morbidity for T2DM. READ MORE