Search for dissertations about: "type III secretion"

Showing result 16 - 20 of 177 swedish dissertations containing the words type III secretion.

  2. 16. The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes

    Author : Tasnim Dayeh; Diabetes - epigenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG-SNP; glucagon secretion; insulin secretion; human pancreatic islets; DNA methylation; Epigenetics;

    Abstract : Islet dysfunction is central to the development and progression of type 2 diabetes (T2D). Epigenetic modifications are essential for establishing and maintaining cell identity and function in normal circumstances. Exposure to adverse environmental factors may alter the epigenome, and result in changes of gene expression and the resulting phenotype. READ MORE

  4. 17. Exploring the mechanistic details of Gram-positive Type 4 Secretion Systems

    Author : Lena Lassinantti; Ronnie Berntsson; A. Elisabeth Sauer-Eriksson; Sjoerd Wanrooij; Samuel Wagner; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antimicrobial resistance; Horizontal gene transfer; Gram-positive bacteria; Type 4 Secretion Systems; Conjugation; Enterococcus faecalis; pCF10; PrgU; PcfF; PrgB; Biochemistry; biokemi;

    Abstract : Hospital acquired (i.e. nosocomial) infections and antibiotic resistance are large issues in the world today, with about 1.3 million people estimated to have died from antibiotic resistant infections in 2019 alone, and these problems are on the rise. READ MORE

  5. 18. Investigations of Strategies to Counteract Proinflammatory Cytokines in Experimental Type 1 Diabetes

    Author : Andreas Börjesson; Stellan Sandler; Annika Carlsson; Jens Nielsen; Uppsala universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Type 1 diabetes; proinflammatory cytokines; SOCS-3; pancreatic islets; inducible nitric oxide synthase; insulin secretion; NOD mice; islet transplantation; proinsulin conversion; streptozotocin; prolactin; Medicine; Medicin;

    Abstract : Type 1 diabetes (T1D) is a chronic autoimmune disease targeted against the pancreatic β-cells. Proinflammatory cytokines are considered to play a major role in the destruction of the insulin-producing β-cells. This thesis studied strategies to counteract proinflammatory cytokines in experimental T1D. READ MORE

  6. 19. From the pancreatic beta cell to the endothelium:Pathophysiological aspects of Type 2 Diabetes

    Author : Marloes Dekker Nitert; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sekretion; diabetologi; diabetology; insulin secretion; beta cells; glucose tolerance; insulin receptors; IGF-I receptors; endothelial cells; Endokrinologi; Type 2 Diabetes; secreting systems; Endocrinology;

    Abstract : The incidence of Diabetes Mellitus increases globally in epidemic proportions. Type 2 Diabetes is the most prevalent form of Diabetes, comprising 90% of the patients. In Type 2 Diabetes, two processes contribute to the development of the disease: insufficient insulin secretion from the pancreatic ?-cell and insulin resistance of the target organs. READ MORE

  7. 20. Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans

    Author : Anders H Olsson; Diabetes - epigenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Genetics; Epigenetics; Human Pancreatic Islets; Oxidative Phosphorylation; Insulin Secretion;

    Abstract : The prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D is a heterogeneous disease caused by a complex interplay between multiple genetic, epigenetic and non-genetic factors. The disease is characterised by impaired insulin secretion from pancreatic β-cells and insulin resistance in peripheral tissues. READ MORE