Search for dissertations about: "type III secretion"

Showing result 21 - 25 of 177 swedish dissertations containing the words type III secretion.

  2. 21. Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion

    Author : Sofia A Andersson; Diabetes - öcellsexocytos; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Insulin; Glucagon; Alpha-cells; Beta-cells; Exocytosis; Capacitance; SNARE; SNAP25; Syntaxin1A; Synaptotagmin; Munc-18 Stxbp1 ; SNP; Expression; miRNA;

    Abstract : Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). READ MORE

  4. 22. Dissecting the role of micro-RNAs in diabetes

    Author : Caroline Bolmeson; Create Health; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Type 2 diabetes; micro-RNA; Dicer; beta-cell function; insulin secretion; glucose; NOD mouse; Goto-Kakizaki rat; human islets; thymocytes; apoptosis;

    Abstract : The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in human and rodents have been investigated in this thesis. Dicer1 was specifically deleted in vivo in pancreatic β-cells under the RIP-promoter in mice. READ MORE

  5. 23. Small molecule inhibitors of type III secretion and their effect on chlamydia development

    Author : Sandra Muschiol; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chlamydiae are obligate intracellular pathogens that cause a variety of diseases with clinical and public health importance. Like many Gram-negative bacteria, Chlamydiae employ a type III secretion (T3S) system for invasion and establishment of a protected intracellular niche for successful replication and survival within host cells. READ MORE

  6. 24. Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes

    Author : Yuedan Zhou; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TCF7L2; rs7903146; Type 2 diabetes; β cell function; β cell survival; insulin secretion; proinsulin synthesis; proinsulin-to-insulin conversion; insulin maturation; open chromain; exon skipping; p53; TP53INP1; ISL1; MAFA; NEUROD1; PDX1; NKX6.1; PCSK1; PCSK2; SLC30A8; GWAS.;

    Abstract : Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. READ MORE

  7. 25. Multiple twists in the molecular tales of YopD and LcrH in type III secretion by Yersinia pseudotuberculosis

    Author : Petra J Edqvist; Matthew Francis; Olaf Schneewind; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yersinia pseudotuberculosis; T3SS; YopD; translocation process; LcrH; class II chaperone; substrate secretion pathway specificity; Molecular biology; Molekylärbiologi;

    Abstract : The type III secretion system (T3SS) is a highly conserved secretion system among Gram negative bacteria that translocates anti-host proteins directly into the infected cells to overcome the host immune system and establish a bacterial infection. Yersinia pseudotuberculosis is one of three pathogenic Yersinia spp. READ MORE