Search for dissertations about: "tyrosinase"

Showing result 11 - 15 of 15 swedish dissertations containing the word tyrosinase.

  2. 11. Bioelectrochemical Applications of Reactions Catalyzed by Immobilized Enzymes

    Author : Xiao-Jing Tang; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Acetate Kinase.; NAD NADH recycling; Enzyme Electrodes; Enzyme reactors; Enzyme Immobilization; Electrochemical detection; Flow Injection Analysis; Analytical chemistry; Analytisk kemi;

    Abstract : The sensitivity of biosensors can be increased substantially by incorporation in a substrate recycling scheme. Based on the amplification of NAD+/NADH by the recycling reaction catalyzed by glycerol dehydrogenase (GDH) and diaphorase, NAD+/NADH can be determined amperometrically with around 1000 times higher sensitivity than for the substrate sensing mode. READ MORE

  4. 12. Mineral fibers, cigarette smoke, and oxidative DNA damage : An experimental study

    Author : Per Leandersson; Östergötlands Läns Landsting; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : This study concerns the ability of mineral fibers and cigarette smoke to generate reactive oxygen metabolites and to cause damage to DNA. The generation of hydroxyl radicals (OH") was demonstrated by using the DNA base, deoxyguanosine (dG) as a trapping agent for OH" and determining its hydroxylation to 8-hydroxydeoxyguanosine (80HdG), and oxidative DNA damage was assessed as formation of 80HdG in isolated DNA or in DNA of human lung cells in culture. READ MORE

  5. 13. Dynamic regulation of aryl hydrocarbon receptor function and activity by different stimuli

    Author : Sandra Lücke; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cells have to sense and adapt to changes in their surrounding environment. Most of the cellular responses to environmental and developmental stimuli are mediated by PAS (Per-ARNT-Sim) proteins. A member of this family of proteins is the aryl hydrocarbon receptor (AhR), a ligand-activated bHLH transcription factor and E3 ubiquitin ligase. READ MORE

  6. 14. Decellularized liver extracellular matrix as a 3D scaffold for bioengineering applications

    Author : Vamakshi Khati; Aman Russom; Håkan Jönsson; Giulia Gaudenzi; Ana Teixeira; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; liver decellularization; decellularized liver matrix bioink; bioprinting; sacrificial scaffold; viscoelasticity; bioengineering; tumor modeling; stem cell differentiation; bioreactor; Biotechnology; Bioteknologi;

    Abstract : The increasing global burden of end-stage liver disease has increased the need for liver transplantation, the definitive cure. However, there is a huge discrepancy between the number of available organ donors and the number of patients waiting for transplantation, resulting in the deaths of a significant number of patients on the waiting list as only 10% of the global need for transplantation is met. READ MORE

  7. 15. Small molecules that affect the p53 pathway and their potential use in the treatment of cancer

    Author : Marijke Cornelia Christine Sachweh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The tumor suppressor p53 was identified 35 years ago and has since then been studied extensively, but despite all efforts, no drug or therapy directly involving it has been clinically approved - yet! A lot of potential new drugs are on their way that can reactivate p53 function by various mechanisms. Even a whole new approach called cyclotherapy has been established, during which p53 is activated in normal cells to protect patients from the adverse effects of chemotherapy while tumor cells are still being killed efficiently. READ MORE