Search for dissertations about: "tyrosine hydroxylase"

Showing result 1 - 5 of 71 swedish dissertations containing the words tyrosine hydroxylase.

  1. 1. Pteridine dependent hydroxylases as autoantigens in autoimmune polyendocrine syndrome type 1

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Olov Ekwall; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical sciences; APS I; alopecia; autoantigen; cDNA; malabsorption; phenylalanine hydroxylase; pteridine; tryptophan hydroxylase; tyrosine hydroxylase; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Autoimmune polyendocrine syndrome type I (APS) is a monogenous, recessively inherited disease characterised by endocrine and non-endocrine autoimmune manifestations. One fifth of APS I patients suffer from periodic intestinal dysfunction with varying degrees of malabsorbtion, steatorrhea and constipation. READ MORE

  2. 2. Role of Bone Morphogenetic Proteins for Catecholaminergic Neurons in Vivo Use of the Tyrosine Hydroxylase Locus for Cell-Specific inactivation of Signal Transduction

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Dmitry Usoskin; Uppsala universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Tyrosine Hydroxylase; Bone Morphogenetic Proteins BMP ; Transforming Growth Factor-β TGF-β ; tissue-specific knockout; Parkinson s disease; Neurovetenskap; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Neurology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Neurologi;

    Abstract : Members of the Transforming Growth factor-β (TGF-β) superfamily and its subclass Bone Morphogenetic Proteins (BMP) play important roles for nervous system development. In order to study the BMP role for catecholaminergic neurons in vivo, we generated three knock-in mice, expressing the transgenes specifically in the targeting cells. READ MORE

  3. 3. X-ray characterization of PaPheOH, a bacterial phenylalanine hydroxylase

    University dissertation from Umeå : Umeå centrum för molekylär patogenes (UCMP) (Teknisk-naturvetenskaplig fakultet)

    Author : Fredrik Ekström; Umeå universitet.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; PaPheOH; PheOH; PAH; phhA; phenylalanine hydroxylase; protein crystallography; a-actinin; microcrystal; ABD; CH-domain; Biokemi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; biokemi; Biochemistry;

    Abstract : Many human diseases are associated with the malfunction of enzymes in the aromatic amino acid hydroxylase family, e.g. phenylketonuria (PKU), hyperphenylalaninemia (HPA), schizophrenia and Parkinson's disease. READ MORE

  4. 4. Alopecia and vitiligo in autoimmune polyendocrine syndrome type I

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Håkan Hedstrand; Uppsala universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical sciences; APS I; autoantigen; vitiligo; alopecia areata; cDNA-library; immunoscreening; tyrosine hydroxylase; SOX9; SOX10; molecular mimicry; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Autoimmune polyendocrine syndrome type I (APS I) is a recessively inherited disease caused by mutations in a recently identified gene, AIRE, on human chromosome 21. APS I patients are affected by autoimmune destruction of multiple endocrine glands and other organs as well as ectodermal structures. READ MORE

  5. 5. GDNF gene delivery in an animal model of Parkinson's disease. Long-term effects on intact, injured and transplanted dopamine neurons using lentiviral gene transfer

    University dissertation from Biljana Georgievska, Div. Neurobiology, BMC A11, 221 84 Lund, Sweden

    Author : Biljana Georgievska; Lunds universitet.; Lund University.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; Neurology; neuropsykologi; neurofysiologi; neurophysiology; transplantation; tyrosine hydroxylase; tetracycline; striatum; substantia nigra; sprouting; regulation; neuroprotection; lentivirus; gene therapy; GDNF; behavior; dopamine; neuropsychology;

    Abstract : Popular Abstract in Swedish Parkinsons sjukdom är en av de vanligaste neurodegenerativa sjukdomarna och orsakas av en selektiv förlust av dopaminerga neuron i mellanhjärnans substantia nigra (SN). Detta leder till en minskad mängd dopamin (DA) i hjärnans motoriska centrum, striatum, vilket orsakar de karakteristiska symptomen bradykinesi, muskelrigiditet och tremor. READ MORE