Search for dissertations about: "tyrosine hydroxylase"

Showing result 6 - 10 of 72 swedish dissertations containing the words tyrosine hydroxylase.

  2. 6. Modeling pathophysiological aspects of Parkinson’s disease: Manipulating DA handling and alpha-synuclein expression in the nigrostriatal pathway using viral vectors

    Author : Ayse Ulusoy; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; adeno-associated virus; dopamine; α-synuclein; tyrosine hydroxylase; RNAinterference; shRNA; substantia nigra; animal models; dyskinesia;

    Abstract : The pathological hallmark of Parkinson’s disease is dopaminergic neurodegeneration in the substantia nigra pars compacta neurons and accumulation of α-synuclein containing aggregates in the surviving neurons. The cause of cell death in Parkinson’s disease and the involvement of α-synuclein in the pathophysiology of the disease are unknown. READ MORE

  4. 7. Novel strategies for enzyme replacement with gene therapy in models of Parkinson’s disease

    Author : Erik Cederfjäll; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AAV vectors; dopamine; enzyme replacement; gene regulation; GTP cyclohydrolase 1; L-DOPA; tyrosine hydroxylase; Parkinson’s disease;

    Abstract : Parkinson’s disease is a brain disorder characterized by loss of dopaminergic neurons in the midbrain, resulting in the characteristic motor symptoms: resting tremor, rigidity, akinesia and postural instability. Symptomatic treatment is based on reconstituting the loss of dopamine in the brain, primarily by oral administration of its precursor L-DOPA. READ MORE

  5. 8. Gene therapy by enzyme replacement for Parkinson’s disease Optimization of continuous DOPA delivery and development of a candidate vector for clinical application

    Author : Tomas Björklund; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serotonin; Parkinson’s disease; L-DOPA; dyskinesia; GTP cyclohydrolase 1; tyrosine hydroxylase; dopamine; gene therapy; enzyme replacement; gene regulation; aromatic L-amino acid decarboxylase;

    Abstract : The introduction of L-DOPA pharmacotherapy revolutionized the treatment of Parkinson’s disease close to fifty years ago. Before the discovery of dopamine as a neurotransmitter and its involvement in the disease, these patients had very little aid from medication and were bound to a life without movement. READ MORE

  6. 9. Cell and Gene Therapy for Parkinson's Disease: Therapeutic Effect and Modulation of Dyskinesias in the 6-OHDA Rat Model

    Author : Thomas Carlsson; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; Pharmacological sciences; pharmacognosy; pharmacy; neurofysiologi; Medicin människa och djur ; Neurology; neuropsychology; neurophysiology; Neurologi; Medicine human and vertebrates ; Parkinson?s disease; Serotonin; Tyrosine hydroxylase; Ventral mesenchephalon; Motor behavior; L-DOPA; GTP cyclohydrolase 1; Gene therapy; Dyskinesias; Cell transplantation; Dopamine; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : The main pathological feature in Parkinson's disease is the progressive loss of dopamine neurons in the midbrain, which in turn leads to the appearance of motor deficits such as akinesia/bradykinesia (loss/slowness of movements), rigidity, postural imbalance and tremor. To this day, there is no cure for the disease, but there are medications to relieve the symptoms. READ MORE

  7. 10. Cyanide and central nervous system : a study with focus on brain dopamine

    Author : Gudrun Cassel; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CNS; cyanide; dopaminergic system; convulsions; receptor binding; tyrosine hydroxylase; monoamine oxidase; extracellular release; inositol phosphate; GABA; GAD;

    Abstract : The brain is a major target site in acute cyanide intoxication, as indicated by several symptoms and signs. Cyanide inhibits the enzyme cytochrome oxidase. This inhibition causes impaired oxygen utilization in all cells affected, severe metabolic acidosis and inhibited production of energy. READ MORE