Search for dissertations about: "tyrosine kinase inhibitors"

Showing result 1 - 5 of 96 swedish dissertations containing the words tyrosine kinase inhibitors.

  1. 1. Aspects on long-term treatment with tyrosine kinase inhibitors in Chronic myeloid leukemia

    Author : Sofia Jönsson; Göteborgs universitet.; Gothenburg University.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic myeloid leukemia; tyrosine kinase inhibitor; imatinib; molecular response; adherence; mesechymal stem cells; osteoblast differentiation; dasatinib;

    Abstract : Chronic myeloid leukemia (CML) is caused by the tyrosine kinase activity of the oncoprotein BCR-ABL. The introduction of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL has profoundly changed the prognosis of CML. Currently, there are three TKIs approved for treatment of CML, imatinib, nilotinib and dasatinib. READ MORE

  2. 2. The FLT3 Tyrosine Kinase in Leukemia Deciphering the Downstream Signaling Events and Drug-Escape Mechanisms

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Amanda Nordigården; Jan-Ingvar Jönsson; Mickael Sigvardsson; Alexander Vener; Bengt Hallberg; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Acute myeloid leukemia (AML) is a severe disease, which originates in blood-forming cells. Although major advances in understanding the biology of AML, the majority of patients eventually succumb to the disease. READ MORE

  3. 3. Exploiting Drosophila as a model system for studying anaplastic lymphoma kinase in vivo

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Therese Eriksson; Ruth Palmer; Stefan Thor; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic lymphoma kinase; Receptor tyrosine kinase; Jeb; neuroblastoma; actin polymerization; Wasp; Scar; Vrp1; Arp2 3; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Molecular biology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and an oncogene associated with several human diseases, but its normal function in humans and other vertebrates is unclear. Drosophila melanogaster has an ALK homolog, demonstrating that the RTK has been conserved throughout evolution. READ MORE

  4. 4. Studies of PDGF receptor signaling in vitro and in vivo

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Tsioumpekou; Carl-Henrik Heldin; Jean-Baptiste Demoulin; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; signaling; cancer; Erk5; kinase; Cbl; ubiquitination; deubiquitinase; pericytes; tumor growth; angiogenesis; low molecular weight inhibitors;

    Abstract : Platelet-derived growth factor receptor (PDGFR) signaling is essential for proliferation, migration and survival of cells of mesenchymal origin; however, its deregulation has been associated with various diseases, including cancer. The aim of this thesis was to clarify the molecular mechanisms of PDGFR signaling regulation. READ MORE

  5. 5. The receptor tyrosine kinase Met and the protein tyrosine phosphatase PTPN2 in breast cancer

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Cynthia Veenstra; Olle Stål; Gizeh Perez-Tenorio; Pietras Kristian; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Breast cancer is the most common form of cancer in women worldwide and the second leading cause of cancer death. It is a heterogeneous disease and is subdivided into different subtypes, all with different treatment responses and survival outcomes. READ MORE