Search for dissertations about: "tyrosine kinase inhibitors"
Showing result 16 - 20 of 113 swedish dissertations containing the words tyrosine kinase inhibitors.
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16. C-Kit as an Oncogenic Tyrosine Kinase - Regulation and Dysregulation of Signaling Pathways
Abstract : It is well known that increased growth and survival of cancer cells often is a result of dysregulated kinase activity and aberrant kinase signaling. The receptor tyrosine kinase c-Kit and its ligand SCF are contributors to this phenomenon in a variety of human cancers, for example hematological malignancies, germ cell tumors and gastrointestinal stromal tumors. READ MORE
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17. In vitro and in vivo studies of Bruton tyrosine kinase (BTK) mutations and inhibition
Abstract : Bruton tyrosine kinase (BTK) is a non-receptor protein kinase that belongs to the TEC family kinases. It plays an important role in the B-cell receptor signaling pathway (BCR) and its pharmacological inhibition has been demonstrated as an effective strategy for the treatment of B-cell malignancies. READ MORE
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18. Treatment of Experimental Neuroblastoma with Angiogenic Inhibitors
Abstract : Neuroblastoma is a childhood cancer that originates from neuroblasts in the peripheral nervous system. Neuroblastoma show considerable heterogeneity with respect to location, responsiveness to treatment and prognosis. READ MORE
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19. Studies of New Signal Transduction Modulators in Acute Myeloid Leukemia
Abstract : Acute myeloid leukemia (AML) is a life-threatening malignant disorder with dismal prognosis. AML is characterized by frequent genetic changes involving tyrosine kinases, normally acting as important mediators in many basic cellular processes. READ MORE
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20. Modelling the evolution of treatment-induced resistance in Ph+ leukaemias
Abstract : Targeted therapies are a mainstay of modern cancer treatments. Rather than harming rapidly dividing cells in general, targeted therapies work by directly interfering with oncogenic molecular pathways present in a tumour. Consequently, a targeted therapy typically has less severe side effects. READ MORE