Search for dissertations about: "ubiquitin ligases"

Showing result 1 - 5 of 27 swedish dissertations containing the words ubiquitin ligases.

  2. 1. Modulation of nuclear receptor signaling by RBR ubiquitin ligases

    Author : Nina Gustafsson Sheppard; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nuclear receptors (NRs) constitute a superfamily of transcription factors and play important roles in physiology. Transcriptional regulation by NRs can be modulated through interactions with various coregulators that activate or repress transcription through mediating receptor and chromatin modifications as well as communicating with the general transcription factor machinery. READ MORE

  4. 2. EBV membrane protein LMP2A interactions with ubiquitin ligases and a signaling scaffold

    Author : Liudmila Matskova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Epstein-Barr virus EBV ; Latent membrane protein 2A LMP2A . HECTdomain E3 ubiquitin ligase; Shb signaling scaffold. Akt kinase; Tyrosine phosphorylation.;

    Abstract : Over 90% of the adult human population carries Epstein-Barr Virus (EBV). EBV stays for life, striking a balance with the immune system. The virus evades immune elimination by severely restricting its own gene expression. The latent infection is established with the resting memory type B-cell as the reservoir. READ MORE

  5. 3. Interplay between the Myc oncoprotein, cyclin-dependent kinases and E3 ubiquitin ligases

    Author : Hamid Reza Sharifi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mammalian cells grow, divide, and die in a precise and orderly fashion. For cells to grow and maintain their integrity they need to communicate at both intracellular and extracellular level. READ MORE

  6. 4. SUMO and ubiquitin : the yin and yang of IGF-1R function

    Author : Bita Sehat; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tumorigenesis is a multistep process involving genetic and epigenetic alterations that drive the progressive transformation of normal human cells into highly malignant derivatives. The insulin-like growth factor 1 receptor (IGF-1R) plays pivotal roles in cancer. READ MORE

  7. 5. Studying the cell cycle using systems biology and high content characterization of the ubiquitin proteasome system

    Author : Johan Boström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The cell cycle is the process through which our cells grow and divide in a carefully orchestrated and controlled manner. An uncontrolled cell cycle is a basic hallmark of cancer, in which excessive cell growth leads to adverse effects on the tissue- and organ-level. READ MORE