Search for dissertations about: "ubiquitin- associated UBA domain"

Found 2 swedish dissertations containing the words ubiquitin- associated UBA domain.

  2. 1. Regulation of the ubiquitin-proteasome system : characterization of viral and cellular stabilization signals

    Author : Stijn Heessen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Epstein-Barr virus EBV ; glycine-alanine GA repeat; green fluorescent protein GFP ; degron; proteasome; Rad23; ubiquitin; ubiquitin- associated UBA domain;

    Abstract : The ubiquitin-proteasome system plays a fundamental role in virtually every cellular process. Degradation of endogenous proteins by this system is the major source for antigenic peptides that are presented to MHC class I-restricted cytotoxic T cells. READ MORE

  4. 2. To degrade or not to degrade : protein handling by the proteasome

    Author : Christian Heinen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The proteasome, a large multi-subunit protease that degrades proteins, must be able to distinguish between substrates deemed for destruction and accessory proteins that should be spared. The shuttle factor Rad23 operates in close proximity to the proteasome in order to deliver proteins for their degradation. READ MORE