Search for dissertations about: "ubiquitylation"

Showing result 1 - 5 of 16 swedish dissertations containing the word ubiquitylation.

  2. 1. Functional Characterization of the Yeast Tumour Suppressor Homologue Sro7p

    Author : Annabelle Forsmark; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yeast; protein sorting; protein secretion; L 2 GL; tumour suppressor; SRO7; SRO77; ENA1; exocytosis; post-Golgi vesicles; ART5; E3 adaptor; ubiquitylation; ATLGL1; ATLGL2;

    Abstract : Correct targeting of newly synthesized proteins to appropriate domains of the cell membrane is crucial to cellular architecture, polarity and function, making it no surprise that many proteins of the secretory machinery are conserved throughout evolution. This work presents a functional characterisation of the Saccharomyces cerevisiae cell polarity protein and tumour suppressor homologue, Sro7p. READ MORE

  4. 2. F‐box proteins as regulators of oncogenic pathways by ubiquitylation

    Author : Diana Cepeda; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : F-box proteins are the substrate-recognition components of the SCF E3 ubiquitin ligases that catalyze the ubiquitylation of many key cell cycle regulators. Functional studies indicate that the ubiquitin-proteasome system participates in the control of nearly all cellular processes through the timely degradation of short-lived regulatory proteins. READ MORE

  5. 3. Methyltransferase Ash1, histone methylation and their impact on Polycomb repression

    Author : Eshagh Dorafshan Esfahani; Yuri B. Schwartz; Jan Larsson; Dale Dorsett; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Trithorax Group proteins; Polycomb Group proteins; PRC1; PRC2; PRE; histone methylation; histone ubiquitylation; Ash1; SET domain; H3K36; H3K27; Drosophila;

    Abstract : Antagonistic interactions between Polycomb Group (PcG) and Trithorax Group (TrxG) proteins orchestrate the expression of key developmental genes. Distinct maternally loaded repressors establish the silenced state of these genes in cells where they should not be expressed and later PcG proteins sense whether a target gene is inactive and maintain the repression throughout multiple cell divisions. READ MORE

  6. 4. Characterization of F-box proteins and their target substrates in cancer

    Author : Hwee-Fang Ng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Protein degradation, by means of ubiquitylation tagging for subsequent degradation by the ubiquitin-proteasome system (UPS), has opened up a newfound way of protein degradation some three to four decades back. Termed the ‘kiss of death’, this field of study has since sparked off the quest for substrates for the main enzymes executing ubiquitylation, the E3 ligases. READ MORE

  7. 5. Protein Acetylation – A Multifunctional Regulator of TGF-β Signaling

    Author : Maria Simonsson; Johan Ericsson; Eva Grönroos; Marikki Laiho; Uppsala universitet; []
    Keywords : Cell biology; TGF-β; Acetylation; Deacetylation; Acetyltransferase; HDAC; Smad; Transcription; Cellbiologi; MEDICINE; MEDICIN;

    Abstract : Transforming growth factor β (TGF-β) is a member of a large family of cytokines that regulate many crucial events in cells, including proliferation, differentiation, migration and apoptosis. Deregulated TGF-β signaling is associated with various forms of cancers and developmental disorders. READ MORE