Search for dissertations about: "uncoupling protein UCP"

Showing result 1 - 5 of 6 swedish dissertations containing the words uncoupling protein UCP.

  1. 1. The Role of Mitochondrial Uncoupling in the Development of Diabetic Nephropathy

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Malou Friederich Persson; Uppsala universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; mitochondria; Uncoupling Protein-2; Adenosine Nucleotide Transporter; uncoupling; diabetes; diabetic nephropathy; db db; dinitrophenol; Coenzyme Q10; oxygen; rats; mice; Physiology; Fysiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Diabetes is closely associated with increased oxidative stress, especially originating from the mitochondria. A mechanism to reduce increased mitochondria superoxide production is to reduce the mitochondria membrane potential by releasing protons across the mitochondria membrane. READ MORE

  2. 2. Experimental Traumatic Brain Injury and Cell Death - in vivo and in vitro aspects

    University dissertation from Laboratory for Experimental Brain Research

    Author : Gustav Mattiasson; Lunds universitet.; Lund University.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurofysiologi; neuropsychology; Neurology; uncoupling protein; mitochondrial permeability transition; cerebral blood flow; functional outcome; cell death; mitochondria; hippocampus; preconditioning; trauma; Brain; ischemia; neuropsykologi; Neurologi; neurophysiology;

    Abstract : Popular Abstract in Swedish Hjärnskador till följd av skallskador (traumatiska hjärnskador) eller otillräckligt blodflöde (cerebral ischemi) är en av de vanligaste orsakerna till död och invaliditet i västvärlden. De vanligaste orsakerna till traumatiska hjärnskador är fordonsolyckor, fall och våldshandlingar. READ MORE

  3. 3. The pathophysiology of respiratory chain dysfunction

    University dissertation from Stockholm : Karolinska Institutet, Department of Medical Nutrition

    Author : José Pablo Silva; Karolinska Institutet.; Karolinska Institutet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondrial disease; mitochondrial DNA mtDNA ; mitochondrial transcription factor A Tfam ; Cre-loxP; conditional knockout; reactive oxygen species ROS ; superoxide; uncoupling protein UCP ; mitochondrial bioenergeties; energy expenditure;

    Abstract : Mutations of mitochondrial DNA cause a variety of clinical syndromes. It is unclear whether impaired oxidative phosphorylation on its own is the main cause of pathology or whether other factors such as secondary metabolic alterations, enhanced formation of reactive oxygen species (ROS) and induction of apoptosis also may contribute to the clinical phenotype. READ MORE

  4. 4. Insulin resistance in pancreatic cancer

    University dissertation from Stockholm : Karolinska Institutet, Center for Surgical Sciences CFSS

    Author : Bengt Isaksson; Karolinska Institutet.; Karolinska Institutet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic cancer; glucose transport; glucose metabolism; insulin signaling; insulin resistance; uncoupling proteins; obstructive jaundice; IAPP; risk factors.;

    Abstract : The dismal prognosis of pancreatic cancer (PC) is related to metabolic complications of the tumor. Impaired glucose tolerance or diabetes due to insulin resistance, and cachexia are observed early and frequently in these patients. The basic mechanisms of PC-associated insulin resistance and weight loss are not fully understood. READ MORE

  5. 5. Insulin action and secretion after surgical trauma : an experimental study in the rat

    University dissertation from Stockholm : Karolinska Institutet, Center for Surgical Sciences CFSS

    Author : Lisa Strömmer; Karolinska Institutet.; Karolinska Institutet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rat; surgical trauma; insulin resistance; glucose transport; PI 3-kinase; intravenous glucose tolerance test; hyperglycemic clamp; pancreatic islets; lipogenesis; lipolysis; uncoupling proteins;

    Abstract : Physical injury or surgical trauma leads to an endocrine-metabolic response that causes a catabolic state designed to promote the healing process. Insulin resistance and mobilization of endogenous fuel stores are prominent changes in metabolism seen after surgery. READ MORE