Search for dissertations about: "unique molecular identifiers"
Found 4 swedish dissertations containing the words unique molecular identifiers.
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1. Next generation molecular diagnostics using ultrasensitive sequencing
Abstract : Massively parallel sequencing enables the exploration of the genetic heterogeneity within microbial, viral and tumor cell populations. Detecting circulating tumor DNA in blood and other body fluids has the potential to revolutionize molecular diagnostics. READ MORE
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2. Ultrasensitive DNA sequencing using liquid biopsies enables precision medicine
Abstract : Liquid biopsies are minimally invasive and allow repetitive sampling of body fluids. Analysis of cell-free tumor DNA in liquid biopsies can be used as a biomarker for cancer. However, in most clinically relevant liquid biopsies, cell-free DNA is present at low concentrations, contains minute tumor allele frequencies, and is highly fragmented. READ MORE
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3. Counting molecules in cell-free DNA and single cells RNA
Abstract : The field of Molecular Biology got started in earnest with the discovery of the molecular structure of DNA. This lead to a surge of interest into the relationships between DNA, RNA and proteins, and to the development of fundamental tools for manipulating those substances, such as cutting, ligating, amplifying, visualizing and size-selecting DNA. READ MORE
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4. Applications of genomic tools to decode genome function
Abstract : The revolution in sequencing technologies has greatly advanced our understanding of genomes. Many regulatory elements lacking protein-coding ability, such as long non-coding RNAs have been identified and characterized in different biological contexts. READ MORE