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Showing result 1 - 5 of 6 swedish dissertations matching the above criteria.

2. 1. On the Versatility of Microwave-Assisted Chemistry : Exemplified by Applications in Medicinal Chemistry, Heterocyclic Chemistry and Biochemistry

   Author : Kristina M. Orrling; Mats Larhed; Fredrik Almqvist; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microwave-assisted chemistry; malaria; aspartic protease; plasmepsin; PfPM4; PmPM4; PoPM4; PvPM4; inhibitor; unsaturated lactone; unsaturated lactam; unsaturated amide; lactam; Bestmann s ylide; ionic liquid; polymerase chain reaction; thermophilic enzyme; Pharmaceutical chemistry; Läkemedelskemi; Organic synthesis; Organisk syntes; Biochemistry; Biokemi; Biochemistry; biokemi;

   Abstract : Today, the demand for speed in drug discovery is constantly increasing, particularly in the iterative processes of hit validation and expansion and lead optimization. Irradiation with microwaves (MWs) has been applied in the area of organic synthesis to accelerate chemical reactions and to facilitate the generation of new chemical entities since 1986. READ MORE

4. 2. Hydrogenation, Transfer Hydrogenation and Hydrogen Transfer Reactions Catalyzed by Iridium Complexes

   Author : Xu Quan; Pher Andersson; Jonathan Williams; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Iridium catalyst; carbene; N; P - ligand; asymmetric hydrogenation; transfer hydrogenation; hydrogen transfer reaction; alkylation; olefin; ketone; amide; organisk kemi; Organic Chemistry;

   Abstract : The work described in this thesis is focused on the development of new bidentate iridium complexes and their applications in the asymmetric reduction of olefins, ketones and imines. Three new types of iridium complexes were synthesized, which included pyridine derived chiral N,P-iridium complexes, achiral NHC complexes and chiral NHC-phosphine complexes. READ MORE

5. 3. Catalytic Amide Reductions under Hydrosilylation Conditions

   Author : Alexey Volkov; Hans Adolfsson; Andrei K. Yudin; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hydrosilylation; amides; reduction; chemoselectivity; organisk kemi; Organic Chemistry;

   Abstract : This thesis covers the development of catalytic methodologies for the mild and chemoselective reductions of amides. The first part of the thesis describes the use of a Fe(II)/NHC catalyst for the deoxygenation of aromatic tertiary amides to corresponding amines. READ MORE

6. 4. Endogenous activators of the pain receptor TRPV1 From cell to man

   Author : Pouya Movahed Rad; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; cannabinoids; capsazepine; N-acylethanolamines; anandamide; blood Circulation; vasodilation; humans; calcitonin Gene-related Peptide; capsaicin; neurogenic inflammation; nociceptors; TRPV1 protein; pain;

   Abstract : N-acylethanolamines (NAEs) belong to a growing family of endogenous signalling molecules acting on a variety of receptors and ion channels. In 1992, it was reported that the N-acylethanolamine anandamide is present in the brain and activates the central cannabinoid (CB) receptor. READ MORE

7. 5. Syntheses of Allelochemicals for Insect Control

   Author : Olof Smitt; KTH; []
   Keywords : isoprenoids; natural product synthesis; allelochemicals; kairomones; allomones; bisabolane terpenoids; Hylobius abietis; germacrane terpenoids; Neodiprion sertifer; stereoselective synthesis;

   Abstract : This thesis describes the synthetic preparation of somecompounds, which can serve as chemical signals for use in thedevelopment of control methods for pest insects. The compoundssynthesised are of the isoprenoid type and of two kinds:carvone derivatives and germacranes. READ MORE