Search for dissertations about: "unsaturated lactone"

Found 3 swedish dissertations containing the words unsaturated lactone.

  1. 1. On the Versatility of Microwave-Assisted Chemistry : Exemplified by Applications in Medicinal Chemistry, Heterocyclic Chemistry and Biochemistry

    Author : Kristina M. Orrling; Mats Larhed; Fredrik Almqvist; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; microwave-assisted chemistry; malaria; aspartic protease; plasmepsin; PfPM4; PmPM4; PoPM4; PvPM4; inhibitor; unsaturated lactone; unsaturated lactam; unsaturated amide; lactam; Bestmann s ylide; ionic liquid; polymerase chain reaction; thermophilic enzyme; Pharmaceutical chemistry; Läkemedelskemi; Organic synthesis; Organisk syntes; Biochemistry; Biokemi; Biochemistry; biokemi;

    Abstract : Today, the demand for speed in drug discovery is constantly increasing, particularly in the iterative processes of hit validation and expansion and lead optimization. Irradiation with microwaves (MWs) has been applied in the area of organic synthesis to accelerate chemical reactions and to facilitate the generation of new chemical entities since 1986. READ MORE

  2. 2. Sesquiterpenoid unsaturated dialdehydes - Structural properties that affect reactivity and bioactivity

    Author : Mikael Jonassohn; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; mutagenic; autoxidation; dopamine D1 receptor; vanilloid receptor; structure-activity relationships; triacetic acid lactone; amino acids; reactivity; merulidial; warburganal; polygodial; Unsaturated dialdehydes; isovelleral; antimicrobial; cytotoxic; Polymer technology; biopolymers; Polymerteknik;

    Abstract : The natural unsaturated 1,4-dialdehydes warburganal (6), polygodial (14), isovelleral (55) and merulidial (56a) and their corresponding unconjugated aldehyde isomers (121), (15), (108) and (109a) were prepared, and their bioactivity and reactivity towards various nucleophiles were investigated. New synthetic routes to prepare (-)-6 and its isomer (+)-121 from (-)-14, and (+)-109a from (-)-56a, have been developed. READ MORE

  3. 3. GALIELLALACTONE ANALOGUES – SYNTHESIS AND PROPERTIES

    Author : Ritha Gidlöf; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Galiellalactone; one-pot peptide coupling and intramolecular Michael addition; tandem palladium-catalyzed carbonylation intramolecular Diels-Alder; STAT3 inhibition;

    Abstract : Cancer cells use normal cell signalling pathways in a proliferative fashion in order to prolong their own survival. Inhibition of one of the major signal proteins, STAT3 (Signal Transducer and Activator of Transcription 3) has previously been shown to induce apoptosis. READ MORE