Search for dissertations about: "uptake transport"

Showing result 1 - 5 of 246 swedish dissertations containing the words uptake transport.

2. 1. The Hepatobiliary Transport of Rosuvastatin In Vivo

   Author : Ebba Bergman; Hans Lennernäs; Ulf Bondesson; Jack Cook; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rosuvastatin; Biliary excretion; Transport inhibition; Pharmacokinetics; Drug-drug interactions; Hepatobiliary transport; Organic anion transporting polypeptide; OATP; Statins; Gemfibrozil; Cyclosporine; Imatinib; Rifampicin; Canalicular transport; Sinusoidal transport; Hepatic uptake; Hepatic extraction; Biopharmacy; Biofarmaci; Biopharmaceutics; biofarmaci;

   Abstract : In vivo studies of hepatobiliary disposition are challenging. The hepatobiliary system is complex, as its physiological localization, complex cellular structure with numerous transporters and enzymes, and the interindividual variability in protein expression and biliary flow will all affect the in vivo disposition of a drug under investigation. READ MORE

4. 2. Energy Efficient Vehicle Policy: Lessons Learnt : An analysis of the effects of incentive policies on the demand, usage and pricing of energy efficient vehicles

   Author : Jake Whitehead; Joel Franklin; Simon Washington; Anders Karlström; Jonas Eliasson; Bert van Wee; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Energy Efficient Vehicle; Incentives; Policy; Demand; Usage; Pricing; Transportvetenskap; Transport Science;

   Abstract : Encouraging the uptake of energy efficient vehicles (EEVs) is an aspiration of critical importance in a day and age in which we are confronted with the increasingly dire consequences of human behaviour on our planet, and on the planet for generations to come. The transport sector is one of the highest contributors of anthropogenic greenhouse gas emissions, whilst pollution from this sector is responsible for a large proportion of human deaths each and every year. READ MORE

5. 3. Chloride Transport in Concrete under the Frost Action – An Experimental Study

   Author : Bo Li; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; temperature; chloride; concrete; freeze-thaw cycles; water uptake; chloride profile; frost action; transport;

   Abstract : Frost-induced ingress of chloride in concrete is one of the typical transport phenomena of aggressive substances when structures expose to severe environments such as marine tidal zone and de-icing highway in winter seasons. It is well known that Chloride ingress in concrete causes the reinforcement corrosion. READ MORE

6. 4. In Vivo Active Drug Uptake and Efflux at the Blood-Brain Barrier : With Focus on Drug Transport Interactions

   Author : Muhammad Waqas Sadiq; Margareta Hammarlund-Udenaes; Sven Björkman; N. Joan Abbott; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Active uptake transport; Microdialysis; P-glycoprotein; Drug interactions; Species differences; Pharmacokinetics; Pharmacodynamics; NONMEM; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : The blood-brain barrier (BBB) controls the movement of substances into and out of the brain. The tight junctions between endothelial cells and energy dependent transporters in the BBB influence rate and extent of drug distribution to the brain. READ MORE

7. 5. Establishing the mechanistic basis of sugar transport

   Author : Abdul Aziz Qureshi; David Drew; Magnus Wolf-Watz; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; membrane transport; transport energetics; nucleotide-sugar transporters; glucose transporters; malaria; cancer; Biochemistry; biokemi;

   Abstract : Sugar is a vital molecule required for cell viability and homeostasis. Sugar is important for metabolic energy, energy storage, signaling, structure and osmolyte regulation. Transport of sugar represents an important physiological process. READ MORE