Search for dissertations about: "utp"

Showing result 21 - 22 of 22 swedish dissertations containing the word utp.

  2. 21. ADP regulation of insulin secretion and beta-cell apoptosis

    Author : Chanyuan Tan; Kardiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; P2Y; β-cell; ADP; insulin; apoptosis; autocrine; ectonucleotidase;

    Abstract : The aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 and P2Y13 were shown in both mouse pancreatic islets and isolated β-cells using real-time PCR quantification. READ MORE

  4. 22. Exploration of host cells during old world alphavirus infection : modulation of RNA granules and the PI3K/AKT pathway

    Author : Lifeng Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : As obligate intracellular parasites, viruses have to explore and modulate cellular pathways for their survival. Mechanistic studies of virus–host interactions provide a better understanding of viral infection and cellular responses and help to identify potential targets for therapeutic intervention. READ MORE