Search for dissertations about: "uveal melanoma"

Showing result 6 - 10 of 17 swedish dissertations containing the words uveal melanoma.

  2. 6. Uveal melanoma : cytogenetics, molecular biology and tumor immunology

    Author : Charlotta All-Ericsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Uveal melanoma; prognostic markers; treatment; CGH; chromosomal aberrations; HLA; IHC; Western blotting; IGF-1R; c-kit; STT571;

    Abstract : Uveal melanoma is the most common primary intraocular malignancy. The metastatic spread is hematogenous and exclusively to the liver. Although eye-sparing treatments are used more frequently the tumor-related mortality in uveal melanoma is still 30-50%. Only 2% of the patients have detectable metastases at the time of diagnosis. READ MORE

  4. 7. Uveal melanoma and macular degeneration : molecular biology and potential therapeutic applications

    Author : Mario A Economou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Uveal melanoma; exudative AMD; IGF-1R; c-Met; prognostic markers; metastasis; oral treatment; VEGF;

    Abstract : Uveal melanoma is the most common primary intraocular malignant tumor in adults with 30% to 50% of patients that ultimately succumb to metastatic disease, mainly to the liver. Although new diagnostic and therapeutic tools have been developed during the most recent years, only the eye conservation rate has been achieved, while the survival rate remains poor. READ MORE

  5. 8. Computational exploration of cancer genomes

    Author : Joakim Karlsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer genomics; Transcriptomics; Driver genes; Copy number changes; Immunogenomics; Cancer of unknown primary; Uveal melanoma;

    Abstract : Cancer evolves due to changes in DNA that give a cell an advantage at the expense of the remaining organism. These alterations range from individual base substitutions to broad losses or duplications of chromosomal material. READ MORE

  6. 9. Next generation molecular diagnostics using ultrasensitive sequencing

    Author : Stefan Filges; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Liquid biopsy; cell-free DNA; circulating tumor DNA; molecular diagnostics; next-generation sequencing; unique molecular identifiers; melanoma;

    Abstract : Massively parallel sequencing enables the exploration of the genetic heterogeneity within microbial, viral and tumor cell populations. Detecting circulating tumor DNA in blood and other body fluids has the potential to revolutionize molecular diagnostics. READ MORE

  7. 10. Novel immunotherapies for metastatic uveal melanoma - From bench to clinical biomarkers

    Author : Vasu R. Sah; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Immunotherapy has revolutionized cancer treatment, with durable long-term effects in a proportion of patients. However, in around half of these patients, there are little to no effects. Patients with metastatic uveal melanoma (mUM), a rare form of melanoma originating from the eye has lack of effective treatments. READ MORE