Search for dissertations about: "vaccine trial"

Showing result 1 - 5 of 39 swedish dissertations containing the words vaccine trial.

2. 1. Aspects of pertussis, pertussis vaccination and adverse events associated with aluminum adsorbed vaccines

   Author : Elisabet Bergfors; Göteborgs universitet; []
   Keywords : Pertussis; parapertussis; pertussis toxoid; vaccine; vaccination; vaccine trial; adjuvant; aluminium; adsorbed vaccines; adverse event; pruritic nodules; itching nodules; granuloma; sensitisation; hypersensitivity; contact allergy;

   Abstract : The thesis originates in a clinical study of one of the new acellular pertussis vaccines performed in Göteborg in the 1990s. The monocomponent vaccine, pertussis toxoid adsorbed to aluminium hydroxide, had previously been shown to have an efficacy of 71%. READ MORE

4. 2. Infectious and bleeding complications in patients with hematological malignancies : Studies on diagnosis and prevention

   Author : Tobias Svensson; Honar Cherif; Martin Höglund; Jan Sjölin; Christine Wennerås; Uppsala universitet; []
   Keywords : Chronic lymphocytic leukemia; Immunodeficiency; Hypogammaglobulinemia; IgG subclass; Pneumococci; Pneumococcal vaccine; Polysaccharide vaccine; Protein-conjugate vaccine; Aspergillosis; Bronchoalveolar lavage; Invasive fungal disease; Pneumocystis jirovecii pneumonia; Myelodysplastic syndrome; Azacitidine; Eltrombopag; Thrombocytopenia; Thrombopoietin receptor; Oncology; Onkologi;

   Abstract : The overall aim of this thesis is to improve knowledge about the prevention of infectious and bleeding complications in patients with hematological malignancies, primarily in those with chronic lymphocytic leukemia (CLL) and myelodysplatic syndrome (MDS).Hypogammaglobulinemia, impaired production of immunoglobulins (Ig), is an established risk factor for infection, but the impact of IgG pure subclass deficiency (IgG subclass deficiency with adequate production of IgG, IgA, and IgM) has been debated. READ MORE

5. 3. Development of a New Oral Vaccine against Diphtheria and the Study of its Immunogenicity in Mouse and Man

   Author : Niclas Rydell; Ingvar Sjöholm; Sveinbjörn Gizurarson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; oral vaccination; mucosal vaccination; diphtheria; biodegradable; microparticles; starch; CRM197; adjuvant; vaccine; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Abstract : Most pathogens enter the body via mucosal surfaces. In contrast to parenterally administered vaccination, mucosal vaccination has the advantage of eliciting both a systemic and a local mucosal immune response. An oral biodegradable adjuvant with these features would have great potential. READ MORE

6. 4. Vaccine-induced aluminium allergy and long-lasting subcutaneous itching nodules

   Author : Anette Gente-Lidholm; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood vaccine; Adverse event; Aluminium; Aluminium allergy; Itching nodules; Subcutaneous granulomas; Patch test; Tolerance;

   Abstract : Background: Aluminium contact dermatitis is rare even though aluminium is frequently used in antiperspirants and sunscreens. Sensitisation to aluminium is mostly a side effect of aluminium-adsorbed vaccines. These can also induce long-lasting intensely itching subcutaneous nodules (granulomas) at the injection site. READ MORE

7. 5. Targeting the human papillomavirus for prevention of cervical cancer

   Author : Pontus Naucler; Malmö Klinisk mikrobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bakteriologi; virologi; Mikrobiologi; mycology; virology; bacteriology; prevention; Microbiology; CIN; vaccine; cervical intraepithelial neoplasia; screening; cervical cancer; Human Papillomavirus; HPV; mykologi; Public health; epidemiology; Folkhälsa; epidemiologi;

   Abstract : Different types of human papillomavirus (HPV) vary in the extent they cause precursor lesions (CIN) and cancer. There are limited long-term efficacy data on HPV testing in primary screening Among 72 cervical cancers in Mozambique, HPV 16 and 18 were the most frequent HPV types (69% of cases). READ MORE