Search for dissertations about: "vaccines"
Showing result 1 - 5 of 325 swedish dissertations containing the word vaccines.
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1. Rift Valley fever : development of diagnostics and vaccines
Abstract : Rift Valley Fever virus (RVFV) causes an infection with severe impact on animal and human health. The disease is endemic throughout almost the entire African continent and large regions of the Arabian Peninsula. During epidemics, high mortality is observed in animals, especially among cattle, goats, and sheep. READ MORE
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2. Recombinant subunit vaccines : protein immunogens
Abstract : Recombinant techniques provide valuable tools for thedevelopment of modern subunit vaccines. In this thesisdifferent systems for production of recombinant subunitvaccines are presented. The strategies investigated includeprotein immunogens, live bacterial vectors and nucleicacids. READ MORE
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3. Surface expression using the AIDA autotransporter : Towards live vaccines and whole-cell biocatalysis
Abstract : The area of surface expression has gathered a lot of interest from research groups all over the world and much work is performed in the area. Autotransporters have been used for surface expression in Gram-negative bacteria. READ MORE
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4. Alphavirus vectors as recombinant vaccines
Abstract : This thesis describes further developments of an expression system based on the alphavirus Semliki Forest virus (SFV), and its potential use as recombinant vaccine. The RNA genome of SFV contains a 3'open reading frame (ORF) encoding the structural proteins, and a 5' ORF coding for the viral replicase. READ MORE
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5. Dendritic cells in cancer immunotherapy
Abstract : Dendritic cells (DCs) play a central role in the initiation and regulation of innate and adaptive immune responses and have increasingly been applied as vaccines for cancer patients. Ex vivo generation and antigen loading of monocyte-derived DCs allows a controlled maturation, with the aim of imprinting different DC functions that are essential for their subsequent induction of a T cell-mediated anti-tumor response. READ MORE