Search for dissertations about: "vaccines"

Showing result 11 - 15 of 325 swedish dissertations containing the word vaccines.

  2. 11. Delivery of DNA vaccines against cancer

    Author : Anna-Karin Roos; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA vaccine; prostate-specific antigen; immunotherapy; prostate cancer; electroporation;

    Abstract : DNA vaccines against cancer have shown promising results in animal models. Efficient antigenspecific T cell responses and tumor protection have been demonstrated after vaccination with DNA encoding tumor antigens in mice. READ MORE

  4. 12. Puumala hantavirus : immune responses and vaccines

    Author : Cristina de Carvalho Nicacio; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hantavirus; Puumala virus; nucleocapsid protein; neutralizing antibodies; Fab fragment; combinatorial library; phage-display; IgA; cellular immunity; cross-protection; intranasal vaccination;

    Abstract : Hantaviruses (family Bunyaviridae) is a group of closely related zoonotic rodent-borne viruses that are transmitted to humans through inhalation of infected rodent excreta. They cause hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS) with varying degree of severity depending on the causative virus. READ MORE

  5. 13. Immunogenicity of anti-leishmaniasis vaccines in man

    Author : Iman Nasr Eldin Satti; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Leishmania; cellular immunity; cytokines; Leishmanin skin test.;

    Abstract : Leishmaniasis represents a serious health problem in Sudan. There is no adequate control measure available against the disease in the country. Vaccination remains the optimal potential control measure. READ MORE

  6. 14. Production and delivery of recombinant subunit vaccines

    Author : Christin Andersson; KTH; []
    Keywords : Affibody; Affinity chromatography; Affinity purification; DNA immunization; Expression plasmid; Fusion protein; Hydrophobic tag; Iscoms; Lipid tagging; Malaria; Mammalian cell expression; Recombinant immunogen; Respiratory Syncytial Virus; Semliki Fo;

    Abstract : Recombinant strategies are today dominating in thedevelopment of modern subunit vaccines. This thesis describesstrategies for the production and recovery of protein subunitimmunogens, and how genetic design of the expression vectorscan be used to adapt the immunogens for incorporation intoadjuvant systems. READ MORE

  7. 15. DNA vaccines and bacterial DNA in immunity

    Author : Lisa Charlotta Bandholtz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA vaccine; CpG DNA; antimicrobial peptides C. pneumoniae; Shigella spp;

    Abstract : This thesis describes DNA-based vaccination and the importance of bacterial DNA in different immunological perspectives. Intranasal (i.n.) DNA vaccination utilizing a plasmid encoding the chlamydial heat shock protein 60 (p-hsp-60) generated lower bacterial burden and reduced pathology in the lungs of mice after subsequent infection with C. READ MORE