Search for dissertations about: "vaccines"

Showing result 16 - 20 of 325 swedish dissertations containing the word vaccines.

  2. 16. Improving the immunogenicity of HIV-1 DNA vaccines

    Author : David Hallengärd; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nearly 30 years have passed since the start of the global HIV epidemic and we are still unable to control the spread of the virus. HIV predominately infects cells crucial for the function of the immune system, integrates into the host genome and demonstrates a huge genetic variability, and the use of therapeutic antiretroviral drugs can restrain but not clear the infection. READ MORE

  4. 17. A mouse model for direct evaluation of cholera vaccines

    Author : Erik Nygren; Göteborgs universitet; []
    Keywords : Vibrio cholerae; cholera vaccine; cholera toxin; LPS; anti-bacterial immunity; IgA; challenge; protection; colonization;

    Abstract : Cholera continues to be an important cause of morbidity and mortality in large parts of the developing world and is a significant negative factor for economic development. Vibrio cholerae bacteria of the O1 or O139 serogroup can cause disease due to their ability to colonize the intestine and produce an enterotoxin, cholera toxin (CT). READ MORE

  5. 18. Therapeutic Cancer Vaccines Targeting Molecules Associated with Tumor Angiogenesis

    Author : Julia Femel; Anna-Karin Olsson; Grietje (Ingrid) Molema; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor; therapeutic; cancer vaccine; angiogenesis; vasculature; fibronectin; galectin-1; Medical Cell Biology; Medicinsk cellbiologi; Oncology; Onkologi; Biomedicinsk laboratorievetenskap; Biomedical Laboratory Science; Medical Science; Medicinsk vetenskap;

    Abstract : Induction of an endogenous antibody response by therapeutic vaccination could provide an alternative to cost-intensive monoclonal antibody-based treatments for cancer. Since the target of a cancer vaccine will most likely be a self-antigen, self-tolerance of the immune system must be circumvented. READ MORE

  6. 19. Strategies to enhance the potency of HIV-1 DNA vaccines

    Author : David Hallengärd; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Despite 30 years of intense research on HIV/AIDS, we have yet to arrive at a prophylactic vaccine that confers complete protection. This mission is complicated by the virus’s vast genetic variability and its ability to mask the targets for neutralizing antibodies. READ MORE

  7. 20. Analytical Quality by Design Method Development for Vaccine Characterization

    Author : Lars Geurink; Catharina Sänger van de Griend; Mikael Hedeland; Martijn Schenning; Iulia Oita; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; viral vaccines; adenovirus; influenza; polio; COVID; corona; capillary electrophoresis; analytical quality by design; analytical method development; CGE; icIEF; CZE; crude cell suspension analysis; in-process sample analysis; quality control testing; biopharmaceutical characterization; Analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : Vaccines that are safe, efficacious, and can be rapidly developed are needed to prevent and to react to emerging global infectious disease threats such as influenza, Polio, and Coronavirus diseases. Fast and reliable analytical methods are required without delay to support vaccine process and product development, characterization, and quality control testing. READ MORE