Search for dissertations about: "valentina paloschi"

Found 1 swedish dissertation containing the words valentina paloschi.

2. 1. Bicuspid aortic valve-associated aortopathy unraveling the molecular signature

   Author : Valentina Paloschi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Patients with bicuspid aortic valve (BAV) have an increased risk of developing ascending aortic aneurysm compared with individuals with a tricuspid aortic valve (TAV). A crucial factor involved in vascular remodeling during aneurysm development is transforming growth factor-β (TGF-β) and impaired signaling of this pathway can alter important extracellular matrix (ECM) protein such us fibronectin and collagen and thereby explaining the increased aneurysm susceptibility of BAV patients. READ MORE