Search for dissertations about: "vandetanib"

Showing result 1 - 5 of 7 swedish dissertations containing the word vandetanib.

  2. 1. Prognostic Biomarkers and Target Proteins for Treatment of High-grade Gliomas

    Author : Linda Sooman; Simon Ekman; Johan Lennartsson; Joachim Gullbo; Michael Bergqvist; Erik Blomquist; Stefan Bergström; Beatrice Melin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-grade glioma; prognostic biomarkers; combination chemotherapy; DNA methylation; FGF2; p38 MAPK; PTPN6; camptothecin; imatinib; vandetanib; EGFR; RAC1; Notch; Medical Science; Medicinsk vetenskap; Oncology; Onkologi;

    Abstract : The survival for high-grade glioma patients is poor and the treatment may cause severe side effects. A common obstacle in the treatment is chemoresistance. To improve the quality of life and prolong survival for these patients prognostic biomarkers and new approaches for chemotherapy are needed. READ MORE

  4. 2. Experimental combination therapy of brain cancer cell models

    Author : Ana-Maria Marino; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Epigenetic alterations and aberrant expression of genes controlling epigenetic mechanisms have been identified in several cancers, including medulloblastoma and glioma, the most common primary brain tumors in children and adults, respectively. We have been investigating if combination therapy using histone deacetylase inhibitors (HDACi) and receptor tyrosine kinase inhibitors (RTKi) will enhance glioblastoma and medulloblastoma cell killing. READ MORE

  5. 3. Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models

    Author : Thomas Asklund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glioma; gap junction; Cx43; bystander effect; HSV-tk; HDAC inhibitor; tyrosine kinase inhibitor;

    Abstract : The group of patients suffering from the malignant brain tumour glioblastoma multiforme (GBM) have a median survival of only about one year. Thus, new treatment strategies are urgently needed. Gap junctions are intercellular channels, permitting intercellular transfer of water soluble substances. READ MORE

  6. 4. Multivariate analyses of proteomic and metabolomic patterns in brain tumors

    Author : Carl Wibom; A Tommy Bergenheim; Henrik Antti; Mikael Johansson; Janne Lehtiö; Umeå universitet; []
    Keywords : glioblastoma; meningioma; proteomics; metabolomics; multivariate analyses; onkologi; Oncology;

    Abstract : Glioblastoma multiforme (GBM) is the most common primary brain tumor. Given the current standard of care, the prognosis for patients diagnosed with this disease is still poor. There consequently exists a need to improve current treatments, as well as to develop new ones. READ MORE

  7. 5. Strategies for optimisation of 177Lu-octreotate therapy – exploring local administration and combination therapy regimens

    Author : Viktor Sandblom; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peptide receptor radionuclide therapy; PRRT; 177Lu-octreotate; Neuroendocrine tumours; Optimisation; Local administration; Combination therapy;

    Abstract : Neuroendocrine tumours (NETs) are a group of heterogeneous tumour types that originate in hormone-producing organs. Patients with NETs are often diagnosed after the primary tumour has metastasised. READ MORE