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Showing result 1 - 5 of 20 swedish dissertations matching the above criteria.

  2. 1. Vascular Interactions in Innate Immunity and Immunothrombosis: : Models of Endothelial Protection

    Author : Sofia Nordling; Peetra Magnusson; Paul Kubes; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endothelial cells; Thrombosis; Innate immunity; Immunothrombosis; Thromboinflammation; Immunologi; Immunology;

    Abstract : The phenomenon known as immunothrombosis has garnered increased attention over the last few years. Much work has been done to characterize the cross talk between hemostasis and the innate immune system. READ MORE

  4. 2. Investigating histidine-rich glycoprotein and T cell-specific adaptor as potential biomarkers and therapeutic targets

    Author : Tor Persson Skare; Lena Claesson-Welsh; Mats Hellström; Elin Sjöberg; Jonas Fuxe; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Histidine-rich glycoprotein; T cell-specifik adaptor; Lymphoma; Glioblastoma; Vascular permeability;

    Abstract : The endothelial cell (EC), the most important cell type in blood vessels, lines the vessel wall and provides vessel integrity. EC function is tightly regulated, and its dysregulation is a key element in many diseases including cardiovascular disease, cancer and several diseases of the eye. READ MORE

  5. 3. Interaction of human blood platelets, lymphocytes and monocytes with vascular laminin isoforms

    Author : Gezahegn Gorfu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Vascular laminin isoforms; extracellular matrix; integrins; cell adhesion; cell migration; high endothelial venules; lymphocytes; monocytes; platelets; leukocyte extravasation;

    Abstract : Inflammatory and immune responses play a fundamental role in both health and disease, and leukocytes are important actors in these processes. Migration of the leukocytes to sites of injury or inflammation is a crucial component of innate and adaptive immunity. It is currently accepted that leukocyte extravasation is a multistep process. READ MORE

  6. 4. Mechanisms of endothelial cell dysfunction in Wegener's granulomatosis

    Author : Carolina Holmén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Wegener´s granulomatosis; vasculitis; anti-endothelial cell antibody; circulating endothelial cell; vascular adhesion protein 1; MHC class-I related chain A;

    Abstract : Vasculitides are a heterogeneous group of disorders that share a common feature of blood vessel inflammation. A major cell type of the blood vessel affected is the endothelial cell (EC). READ MORE

  7. 5. Engineering the shape of bacterial cellulose and its use as blood vessel replacement

    Author : Henrik Bäckdahl; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; tissue engineering.; smooth muscle cells; bacterial cellulose; scaffold design; tubular fermentation; biocompatibility evaluation; Blood vessel; vascular graft;

    Abstract : Tissue loss and organ failure are major health problems that impose great costs on society. Cardiovascular diseases are responsible for 36% of mortalities and the disease burden among adults over the age of 60. The single largest cardiovascular disease is atherosclerosis in the coronary artery. READ MORE