Search for dissertations about: "vascular endothelial-cells"

Showing result 1 - 5 of 237 swedish dissertations containing the words vascular endothelial-cells.

  2. 1. Functional genomics of vascular endothelial cells

    Author : Elisabet Wallgard; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Vasculature; endothelial cells; angiogenesis; vascular endothelial growth factor VEGF ; Notch; transcriptome; genomics; microarray; tumor; retina; morpholino knockdown;

    Abstract : Angiogenesis, the formation of new blood vessels from preexisting ones, is a process involved in normal development as well as in several pathological conditions, such as cancer, ischemic heart disease, wound healing and certain retinal complications. Antiangiogenic targeting is therefore a promising new therapeutic principle. READ MORE

  4. 2. Endothelial cells : dysfunction and repair mechanisms

    Author : Elzafir Elsheikh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Endothelial cells; endothelial progenitor cells; Wegener s granulomatosis; atherosclerosis; myocardial infarction; menstruation cycle; stromal cell-derived factor-1;

    Abstract : Endothelial cells (ECs) are crucial component of the normal vascular wall, providing an interface between the bloodstream and surrounding tissue of the blood vessel wall. Endothelial progenitors cells (EPCs) circulate in the blood and migrate to regions of the circulatory system with injured endothelium and ischemic tissues. READ MORE

  5. 3. From endothelial cells to the vascular network : How cell migration and proliferation are orchestrated to build lymphatic vessels

    Author : Di Peng; Katarzyna Koltowska; Vermot Julien; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lymphangiogenesis; Cell migration; Zebrafish; Biologi med inriktning mot zoologisk utvecklingsbiologi; Biology with specialization in Animal Development;

    Abstract : Lymphatic endothelial cells (LECs) migrate across body to form a branched network, which is crucial for fluid drainage and immune cell trafficking of the tissues. However, the molecular mechanisms behind the spatiotemporal regulation and fine-tuning of LEC migration remain largely unknown. READ MORE

  6. 4. The Role of Shb in Angiogenesis, FGF and VEGF Signalling in Endothelial Cells

    Author : Kristina Holmqvist; Michael Welsh; Eva Degerman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Shb; Src; FAK; Angiogenesis; VEGFR-2; FGFR-1; Endothelial cells; Spreading; Stress fiber formation; siRNA; VEGF; FGF; Differentiation; Migration; Tube formation; RNAi; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Abstract : Angiogenesis is defined as the formation of new capillary blood vessels from pre-existing ones. This process involves several steps including: migration, proliferation and differentiation of endothelial cells into blood vessels. READ MORE

  7. 5. TGFβ Signal Transduction in Endothelial Cells

    Author : Gudrun Valdimarsdóttir; Peter ten Dijke; Carl-Henrik Heldin; Christer Betsholtz; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi;

    Abstract : Transforming growth factor β (TGFβ) is a multifunctional cytokine that is involved in many biological effects, such as proliferation, migration, differentiation and cell survival. TGFβ regulates cellular responses by binding to a heteromeric complex of type I and type II serine/threonine kinase receptors. READ MORE