Search for dissertations about: "vascular malformation"
Showing result 1 - 5 of 8 swedish dissertations containing the words vascular malformation.
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1. The role of endoglin in vascular patterning and malformation across diverse vascular beds
Abstract : During development, numerous processes must be finely orchestrated to construct a functional vasculature, essential to sustain life. Hereditary haemorrhagic telangiectasia is a disease characterised by the development of arteriovenous malformations and it is caused in over 80% of the cases by mutations in either endoglin (ENG) or ALK1. READ MORE
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2. Cellular and molecular roles for CDC42 in angiogenesis
Abstract : Angiogenesis is the physiological process by which new blood vessels grow and critically depends on the interplay between the major vascular units: endothelial cells, pericytes and smooth muscle cells. Dysfunction and mispatterning of blood vessels are associated with the progression of many vascular complications, and therefore, understanding the causes of vascular dysmorphia is a central question in vascular biology. READ MORE
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3. Inflammation and immunothrombosis in cerebral cavernous malformation : Novel molecular targets for the treatment of an incurable disease
Abstract : Cerebral cavernous malformation (CCM) is a vascular disease that causes mulberry-like lesions (cavernomas) in the central nervous system (CNS). Cavernomas are fragile, leaky and prone to rupture which may cause symptoms such as epileptic seizures, focal neurological deficits and hemorrhagic strokes. CCM lesions can appear sporadically in 0. READ MORE
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4. Vascular function in bicuspid aortic valve disease
Abstract : The aortic valve normally consists of three cusps (tricuspid aortic valve, TAV), but in 0.5-2% of the population it consists of only two cusps (bicuspid aortic valve, BAV), which is the most common congenital cardiac malformation. READ MORE
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5. Cell-autonomous and paracrine mechanisms underlying Pik3ca-driven vascular malformations
Abstract : Vascular malformation is a benign overgrowth of blood or lymphatic vessels leading to life-threatening consequences for affected patients. Activating mutations in the TIE2 receptor cause the majority of venous malformations (VMs), while somatic activating mutations in PIK3CA, leading to the overactivation of the PI3K-AKT pathway, cause both VMs and lymphatic malformations (LMs). READ MORE