Search for dissertations about: "vemurafenib"

Showing result 1 - 5 of 11 swedish dissertations containing the word vemurafenib.

  2. 1. Experimental treatment of patients with disseminated malignant melanoma

    Author : Aglaia Schiza; Gustav Ullenhag; Angelica Loskog; Sara Mangsbo; Thomas Tötterman; Ola Winqvist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Malignant melanoma; AdCD40L; immunotherapy; proteomics; DW-MRI; FDG-PET CT; prediction; early response; BRAF-inhibitor; vemurafenib; Oncology; Onkologi;

    Abstract : Malignant melanoma (MM) is the deadliest skin cancer with an ever-increasing incidence. New treatments have improved the prognosis for patients with advanced MM. Still, most patients do not respond, and the side effects can be severe, underlining the need for better therapies. READ MORE

  4. 2. Functional analysis of long non-coding RNAs in cancer

    Author : Linda Vidarsdottir; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : For years the functional role of noncoding RNAs was greatly underestimated. Whole genome RNA sequencing projects that unraveled pervasive transcription emitting from large parts of the human genome changed those perspectives and prompted scientists to further look into the involvement of noncoding RNAs (ncRNAs) in development and disease. READ MORE

  5. 3. Characterization of non-coding RNAs in cancer

    Author : Per Johnsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : While originally though to only code for proteins, it now stands clear that RNA is a multifunctional molecule involved in a great variety of molecular processes. Recent advances in genome-wide platforms have revealed underappreciated roles of non-protein coding RNAs (ncRNAs). READ MORE

  6. 4. Pro-senescence therapy by targeting MYC and its network as a strategy to combat cancer

    Author : Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer is defined as abnormal cell proliferation with the potential of metastasis and is an increasing threat to global health as the population becomes older. Cancer is triggered by gain-of-function mutations in oncogenes and loss of function mutations in tumor suppressor genes. READ MORE

  7. 5. Unravelling molecular mechanisms underlying therapy resistance in cutaneous melanoma

    Author : Alireza Azimi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : For many years the standard treatment of advanced metastatic melanoma with chemotherapeutic agents, including temozolomide (TMZ) and dacarbazine (DTIC), has been unsuccessful. The paradigm shift in melanoma treatment occurred with the identification of mutations in the BRAF gene that leads to a constitutively active BRAF V600E protein. READ MORE