Search for dissertations about: "venlafaxine"

Showing result 1 - 5 of 6 swedish dissertations containing the word venlafaxine.

  2. 1. Antidepressant drug effects in vivo: Focus on pharmacokinetic and pharmacodynamic responses in different experimental paradigms

    Author : Cecilia Wikell; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; portacaval shunt; pharmacokinetics; pharmacodynamics; hepatic encephalopathy; enantiomers; drug safety; drug disposition; citalopram; antidepressants; brain microdialysis; behaviour; venlafaxine; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : Pharmacokinetic and pharmacodynamic activities of the antidepressants venlafaxine (VEN) and citalopram (CIT) were investigated in the portacaval shunted (PCS) rat, a model of chronic hepatic encephalopathy (HE), and normal/control rats. The levels of VEN in serum and brain were higher in PCS rats than in controls after a single injection and chronic treatment with VEN (10 mg/kg). READ MORE

  4. 2. Genetic influence on enantiomeric drug disposition : Focus on venlafaxine and citalopram

    Author : Maria Kingbäck; Fredrik Kugelberg; Björn Carlsson; Martin Josefsson; Finn Bengtsson; Johan Ahlner; Anders Rane; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : A molecule that is not identical to its mirror image is said to be chiral. A racemic mixture, or a racemate, is one that has equal amounts of S- and R-enantiomers of a chiral molecule. Two examples of frequently prescribed racemic drugs are the antidepressants venlafaxine (VEN) and citalopram (CIT). READ MORE

  5. 3. Characterization of secretory mechanisms in lacrimal and salivary glands

    Author : Martin Dankis; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dry mouth; dry eyes; antidepressant; muscarinic; purinergic; salivary secretion; tear secretion; lacrimal gland; in vivo; primary culture; co-culture; acinar; myoepithelial;

    Abstract : Dry mouth and dry eyes are multifactorial morbidities that can lead to a severely reduced quality of life. Approximately 20% of the population suffers from ocular or oral dryness. READ MORE

  6. 4. Drug use during pregnancy with focus on antidepressants

    Author : Emelie Wolgast; Ann Josefsson; Caroline Lilliecreutz; Margareta Reis; Karin Sjöström; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Background: More than half of pregnant women use at least one prescribed medication during pregnancy, and almost all pregnant women use some kind of over-the-counter medication. Depression is one of the most common diseases in the world today, also during the peripartum period. READ MORE

  7. 5. P-glycoprotein and chiral antidepressant drugs : Pharmacokinetic, pharmacogenetic and toxicological aspects

    Author : Louise Karlsson; Fredrik C. Kugelberg; Finn Bengtsson; Johan Ahlner; Aleksander A. Mathé; Linköpings universitet; []
    Keywords : ;

    Abstract : The blood-brain barrier (BBB) is formed by the capillary endothelial cells, joined together by tight junctions, with transporter proteins. BBB acts to regulate the brain concentrations of substances including many drugs. READ MORE