Search for dissertations about: "venous thrombosis"

Showing result 16 - 20 of 76 swedish dissertations containing the words venous thrombosis.

2. 16. Structural pathology and functional analysis of vitamin K-dependent protein S

   Author : Tusar K Giri; Malmö Klinisk kemi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C4b-binding protein; Protein S; blood coagulation; thrombosis; natural mutations; in vitro characterization.; Immunology; transplantation; serologi; Immunologi; serology;

   Abstract : Protein S deficiency is an autosomal dominant trait affecting around 10% of families thrombophilic families. The high affinity interaction of approximately 60% of protein S with C4b -binding protein (C4BP) has raised a complicated situation for the diagnosis of deficiency states. READ MORE

4. 17. Streptococcus pyogenes - a manipulator of human defences

   Author : Fredrik Kahn; Infektionsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus pyogenes; M protein; neutrophils; platelets; platelet-neutrophil complexes; fibrinogen; IgG; abscess; venous thrombosis; heparin binding protein; thrombocytopenia;

   Abstract : Streptococcus pyogenes is a major human pathogen with more than 500 000 casualties annually of which at least 163 000 are due to invasive infections. The remainder is due to post-streptococcal complications with rheu¬matic heart disease constituting the majority. S. READ MORE

5. 18. Venous thromboembolism: Risk factors, comorbidities, and treatment-associated risk of bleedings

   Author : Katarina Glise Sandblad; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Venous thromboembolism; Registries; Overweight; Body mass index; Incidence; Cardiovascular disease; Anticoagulants; Apixaban; Rivaroxaban; Warfarin; Hemorrhage;

   Abstract : Background: Venous thromboembolism (VTE) is the third most common cardiovascular disease, consisting mainly of deep vein thrombosis (DVT) and pulmonary embolism (PE). Since VTE often is a preventable disease, knowledge of risk factors is critical. Following a VTE, many patients are subjected to extended anticoagulant treatment. READ MORE

6. 19. Treatment of deep vein thrombosis and risk of recurrent venous thromboembolism

   Author : Per Lindmarker; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Deep vein thrombosis; pulmonary embolism; low molecular mass heparin; therapy; outpatients; recurrent; risk factors; APC-resistance; factor V G1691A; prothrombin G20210A; side;

   Abstract : A cute deep vein thrombosis (DVT) and pulmonary embolism (PE) are different clinical presentations of the same underlying disease, namely venous thromboembolism (VTE), which is a common and potentially fatal condition. Risk factors associated with the first and probably also subsequent events of VTE are hereditary or acquired. READ MORE

7. 20. Direct Thrombin Inhibitors in Treatment and Prevention of Venous Thromboembolism: Dose – Concentration – Response Relationships

   Author : Marie Cullberg; Mats O. Karlsson; Ulf G. Eriksson; Nick H.G. Holford; Uppsala universitet; []
   Keywords : Pharmaceutical biosciences; Ximelagatran; pharmacokinetic; pharmacodynamic; activated partial thromboplastin time; utility function; dosing strategy; venous thromboembolism; NONMEM; Farmaceutisk biovetenskap;

   Abstract : For prevention and treatment of thrombotic diseases with an anticoagulant drug it is important that an adequate dose is given to avoid occurrence or recurrence of thrombosis, without increasing the risk of bleeding and other adverse events to unacceptable levels. The aim of this thesis was to develop mathematical models that describe the dose-concentration (pharmacokinetic) and concentration-response (pharmacodynamic) relationships of direct thrombin inhibitors, in order to estimate optimal dosages for treatment and long-term secondary prevention of venous thromboembolism (VTE). READ MORE