Search for dissertations about: "ventilation-induced lung injury"

Found 4 swedish dissertations containing the words ventilation-induced lung injury.

2. 1. The Immune Response to One-Lung Ventilation : Clinical and Experimental Studies

   Author : Thomas Schilling; Göran Hedenstierna; Hans Hedenström; Thomas Hachenberg; Sven-Erik Ricksten; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; One-lung ventilation; open thoracic surgery; ventilation-induced lung injury; alveolar immune response; bronchoalveolar lavage; propofol; desflurane; cytokines; animal model; mRNA; RT-PCR; Medical laboratory science; Medicinsk laboratorievetenskap; anestesiologi; Anaesthesiology;

   Abstract : One-lung ventilation (OLV) as an established procedure during thoracic surgery may be injurious in terms of increased mechanical stress characterised by alveolar cell stretch and overdistension, increased cyclic tidal recruitment of alveolar units, compression of alveolar vessels and increased pulmonary vascular resistance. This may result in ventilation-induced lung injury with pro-inflammatory cytokine production, leukocyte recruitment and neutrophil-dependent tissue destruction. READ MORE

4. 2. Titrating Open Lung PEEP in Acute Lung Injury : A clinical method based on changes in dynamic compliance

   Author : Fernando Suarez Sipmann; Göran Hedenstierna; Hans Hedenström; Stefan Lundin; Uppsala universitet; []
   Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; PEEP; open lung; recruitment; dead space; electrical impedance tomography; ARDS.; Medicine; Medicin;

   Abstract : The recognition that supportive mechanical ventilation can also damage the lung, the so called ventilation induced lung injury (VILI), has revived the more than 40 year long debate on the optimal level of PEEP to be used. It is established that the prevention of VILI improves patient outcome and that PEEP exerts protective effects by preventing unstable diseased alveoli from collapsing. READ MORE

5. 3. Remote Ischemic Preconditioning and its Effects on the Respiratory System

   Author : Astrid Bergmann; Anders Larsson; Göran Hedenstierna; Thomas Hachenberg; Ola Winsö; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; one-lung ventilation; ventilation-induced lung injury; alveolar immune response; remote ischemic preconditioning; exhaled nitric oxide; animal model; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

   Abstract : Mechanical ventilation in itself can lead to pulmonary damage, and one-lung ventilation (OLV), necessary for thoracic surgery, accentuates this injury. Remote ischemic preconditioning (RIP) is a potential tool to reduce lung injury after mechanical ventilation, including OLV.  However, current data on pulmonary RIP-effects are contradictory. READ MORE

6. 4. Aspects on ventilation induced stress and strain on regional and global inflammation in experimental acute respiratory distress syndrome

   Author : Jaime Retamal Montes; Anders Larsson; Göran Hedenstierna; Alejandro Bruhn; Björn Jonson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ARDS; VILI; respiratory rate; strain; PET;

   Abstract : Mechanical ventilation (MV) is a life-saving therapy in acute respiratory distress syndrome (ARDS), a condition that affects 3000 patients/year in Sweden with a mortality rate of about 40%. However, MV may induce or worsen lung injury causing “ventilator-induced lung injury (VILI)”. READ MORE