Search for dissertations about: "very low-density lipoprotein"

Showing result 11 - 15 of 34 swedish dissertations containing the words very low-density lipoprotein.

  2. 11. Studies on cholesterol and lipoprotein metabolism : emphasis on diabetes and sugar

    Author : Johanna Apro; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cholesterol has important functions in the body; as a precursor in the synthesis of steroid hormones and bile acids (BAs), and as a component of cellular membranes. However, an elevated level of plasma cholesterol, transported in low density lipoprotein (LDL) particles, is one of the major risk factors and causes for cardiovascular disease. READ MORE

  4. 12. Triglyceride-rich lipoproteins : postprandial metabolism and composition in relation to atherosclerosis

    Author : Johan Björkegren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : triglyceride-rich lipoproteins; very low density lipoproteins; chylomicrons; lipoprotein remnants; apolipoprotein E and C; cholesterol; atherosclerosis;

    Abstract : A relationship between postprandial lipaemia and coronary heart disease (CHD) was established as early as the 1950s. Since then, most attention has been paid to postprandial triglyceride-rich lipoproteins (TRLs) of intestinal origin, i.e. chylomicrons and chylomicron remnants, whereas TRLs of hepatic origin, i. READ MORE

  5. 13. Regulation of plasminogen activator inhibitor-1 : role of triglyceride-rich lipoproteins, fatty acids and fibrate compounds

    Author : Lennart Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : plasminogen activator inhibitor-1; coronary heart disease; endothelial cells; very low density lipoprotein VLDL ; 4G 5G polymorphism; VLDL response element; fibrate compounds; VLDL receptor; stroke;

    Abstract : Impaired fibrinolytic function secondary to elevated plasma plasminogen activator inhibitor-1 (PAI-1) activity is associated with atherothrombotic disease, in particular coronary heart disease. Both environmental and genetic factors contribute to determine plasma PAI-1 levels and PAI-1 production in vivo. READ MORE

  6. 14. Studies on the assembly and secretion of apolipoprotein B containing lipoproteins

    Author : Karin Lindberg; Göteborgs universitet; []
    Keywords : apolipoprotein B; lipoprotein; lipoprotein biosynthesis; Brefeldin A; microsomal triglyceride transfer protein; liver fatty acid binding protein;

    Abstract : Lipoproteins are water-soluble particles of lipids and proteins, which deliver water-insoluble lipids from intestine or liver to target tissues where the lipids are used as fuel or storage. Lipoproteins consist of a core of hydrophobic lipids surrounded by an amphipatic monolayer of polar lipids and specific proteins, apolipoproteins. READ MORE

  7. 15. Studies on organochlorine environmental contaminants with emphasis on analytical methods and occurrence in humans

    Author : Cecilia Weistrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Methods for multicomponent analysis of lipophilic organochlorine contaminants(OCs) in blood plasma and lipid-rich tissues are presented. By using the described methods, polychlorinated biphenyls (PCB), polychlorinated naphthalenes (PCN), hexachlorobenzene(HCB), 1,1-dichloro-2,2-bis(4 chlorophenyl)ethene (p,p'-DDE) and methylsulphonyl metabolites of PCB (MeSO2-PCB) and p,p'-DDE (Meso2-DDE) were determined in human blood plasma, adipose tissue and liver. READ MORE